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TranscriptomicsPaf1C plays novel subunit-specific roles in alternative cleavage and polyadenylation
The PAF complex (Paf1C) has been shown to regulate chromatin modifications, gene transcription, and PolII elongation. Here, we provide the first genome-wide analysis of chromatin occupancy by the entire PAF complex in mammalian cells. We show that Paf1C is recruited not only to promoters and gene bo...
ORGANISM(S): Mus musculus 
2016-01-15 | E-GEOD-72574 | biostudies-arrayexpress
MetabolomicsThe trans-omics landscape of COVID-19
The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 2...
2021-10-06 | MTBLS2542 | MetaboLights
TranscriptomicsThreonine-4 of the budding yeast RNAP II CTD couples transcription with Htz1-mediated chromatin remodeling
The C-terminal domain (CTD) of the largest subunit of RNA polymerase II (RNAP II) consists of repeated YSPTSPS heptapeptides and connects transcription with cotranscriptional events. Threonine-4 (Thr4) of the CTD repeats has been shown to function in histone mRNA 3'-end processing in chicken cells a...
ORGANISM(S): Saccharomyces cerevisiae 
2014-08-08 | E-GEOD-60181 | biostudies-arrayexpress
TranscriptomicsTranscriptional activity regulates alternative cleavage and polyadenylation
Genes containing multiple polyadenylation (polyA) sites express mRNA isoforms with variable 3’ untranslated regions (3’UTRs). We found that short and long 3’UTR isoforms were relatively more abundant when genes were highly and lowly expressed, respectively, in human and mouse cells. Consistently, up...
ORGANISM(S): Mus musculus 
2011-08-15 | E-GEOD-26512 | biostudies-arrayexpress
UnknownBlood T cell diversity associated with the prognosis of advanced non-small cell lung carcinoma treated with first-line pemetrexed based chemotherapy.
Not available
S-EPMC8017263 | biostudies-literature
UnknownIdentification of novel and diverse rotaviruses in rodents and insectivores, and evidence of cross-species transmission into humans.
Not available
S-EPMC7173014 | biostudies-literature
TranscriptomicsRBBP6 isoforms regulate the human polyadenylation machinery and modulate expression of mRNAs with AU-rich 3' UTRs
Polyadenylation of mRNA precursors is mediated by a large multisubunit protein complex. Here we show that RBBP6 (retinoblastoma-binding protein 6), identified initially as an Rb- and p53-binding protein, is a component of this complex and functions in 3' processing in vitro and in vivo. RBBP6 associ...
ORGANISM(S): Homo sapiens 
2014-11-06 | E-GEOD-63036 | biostudies-arrayexpress
TranscriptomicsMethylation profiling by array of human primary prostate cells during the epithelial to mesenchymal transition
Background: Previously we reported extensive gene expression reprogramming during epithelial to mesenchymal transition (EMT) of primary prostate cells. Here we investigated the hypothesis that specific histone and DNA methylations are involved in coordination of gene expression during EMT and early ...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-TABM-982 | biostudies-arrayexpress
TranscriptomicsChIP- chip by array of human primary prostate cells during the epithelial to mesenchymal transition
Background: Previously we reported extensive gene expression reprogramming during epithelial to mesenchymal transition (EMT) of primary prostate cells. Here we investigated the hypothesis that specific histone and DNA methylations are involved in coordination of gene expression during EMT and early ...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-TABM-983 | biostudies-arrayexpress
TranscriptomicsAlternative cleavage and polyadenylation in spermatogenesis coordinates chromatin regulation and post-transcriptional control
Most mammalian genes display alternative cleavage and polyadenylation (APA). Previous studies have indicated preferential expression of APA isoforms with short 3’UTRs in testes. Here we show widespread shortening of 3’UTR by APA during the first wave of spermatogenesis in mouse, with 3’UTRs be...
ORGANISM(S): Mus musculus 
2016-01-11 | E-GEOD-73973 | biostudies-arrayexpress
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