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MetabolomicsNatural polymorphism of ZmICE1 contributes to amino acid metabolism that impacts cold tolerance in maize

Cold stress negatively affects maize (Zea mays L.) growth, development and yield. Metabolic adjustments contribute to the adaptation of maize under cold stress. We show here that the transcription factor INDUCER OF CBF EXPRESSION 1 (ZmICE1) plays a prominent role in reprogramming amino a...

2022-10-31 | MTBLS4404 | MetaboLights
MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Human lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-03 | MTBLS8856 | MetaboLights
MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Mice lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-04 | MTBLS8865 | MetaboLights
TranscriptomicsAcrolein-mediated changes in HUVEC miRNA
Acrolein is a major reactive component of vehicle exhaust, cigarette and wood smoke. It is also present in several food substances and is generated endogenously during inflammation and lipid peroxidation. Although previous studies have shown that dietary or inhalation exposure to acrolein results in...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-56782 | biostudies-arrayexpress
UnknownHewei Jiangni recipe improved the quality of life in patients with cold-heat mixed nonerosive reflux disease: a randomized, double-blinded study.
Not available
S-EPMC12454263 | biostudies-literature
TranscriptomicsUnderstanding the role of Shoc2 protein in spatio-temporal regulation of extracellular signal-regulated kinase (ERK1/2) cascade
This study was designed to understanding changes in RNA transcription in cells depleted of Shoc2 scaffold. 2 samples were analyzed (3 replicates for each sample were included). Cos1 is a control sample.
ORGANISM(S): Chlorocebus sabaeus 
2016-01-15 | E-GEOD-67063 | biostudies-arrayexpress
UnknownHewei Jiangni granule alleviates visceral hypersensitivity of non-erosive reflux diseasestromal interaction molecule 1/transient receptor potential vanilloid subfamily member 1 pathway.
Not available
S-EPMC11764939 | biostudies-literature
UnknownEndogenous protein S100A14 stabilizes glutaminase to render hepatocellular carcinoma resistant to sorafenib.
Not available
S-EPMC11992768 | biostudies-literature
Proteomicsrat myocardial left ventricular tissue proteins LC-MSMS
Rat left ventricular tissue LC-MSMS.Rat left ventricular tissue proteins from different groups were extracted and quantified using the BCA Protein Assay Kit (Thermo Fisher Scientific, USA). The proteins were then labeled with tandem mass tags (TMT). TMT6/10 (Pierce, USA) with different reporter ions...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-07-26 | PXD024641 | Pride
Rat Heart Lc-msms 
TranscriptomicsTime-Dependent Gene Profiling Indicates the Presence of Different Phases for Ischemia/Reperfusion Injury in Retina
The purpose of the present study was to investigate time-dependent changes in gene expression, following induction of IR in the rat retina, and to characterize the affected pathways, networks and processes. 6 biological replicates with two treatments (Sham control and Ischemia reperfusion) and 3 tim...
ORGANISM(S): Rattus norvegicus 
2013-01-24 | E-GEOD-43671 | biostudies-arrayexpress
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