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ProteomicsTNAP - a potential cytokine in the cerebral inflammation in Spastic Cerebral Palsy
Our study was designed to pinpoint the chief molecule playing the specific and critical role in the neuroinflammation in spastic CP, which may provide promising target for diagonosis and treatment of spastic CP. To further our exploration, our future study will focus on the molecular mechanism of ho...
ORGANISM(S): Homo sapiens (Human) 
2022-08-26 | PXD034911 | Pride
Human 
MetabolomicsSex-specific metabolic shifts in plasma of COVID-19 patients after cure
Metabolic profiling in COVID-19 patients has been associated with disease severity, but there is no report on sex-specific metabolic changes in discharged survivors. Herein we used an integrated approach of LC-MS-and GC-MS-based untargeted metabolomics to analyze plasma metabolic characteristics in ...
2022-01-10 | MTBLS2224 | MetaboLights
MetabolomicsMirabegron displays anticancer effects by globally browning adipose tissues

Metabolic reprogramming in malignant cells is a hallmark of cancer that relies on augmented glycolytic metabolism to support their growth, invasion and metastasis. However, the impact of global adipose metabolism on tumor growth and the drug development by targeting adipose metabolism remain larg...

2023-11-08 | MTBLS8682 | MetaboLights
ProteomicshnRNPA1 SUMOylation promotes cold hypersensitivity in chronic inflammatory pain
We show here that the up-regulation of SUMO1-conjugated protein levels in a CFA-induced inflammatory pain model enhances TRPA1 mRNA stability, ultimately leading to increased expression levels.
ORGANISM(S): Homo Sapiens 
PXD046199 |
ProteomicsBone Morphogenetic Protein 9 Protects against Myocardial Infarction by Improving Lymphatic Drainage Function and Triggering DECR1-Mediated Mitochondrial Bioenergetics
We investigated the impact of both BMP9 deficiency and replenishment on the pathogenesis of MI in mice. Our results showed an aggravated pathological phenotype of MI in BMP9 knockout (KO) mice, which can be alleviated by replenishment of BMP9. Therefore, we further investigated the mechanism whereby...
ORGANISM(S): Mus Musculus 
PXD051517 |
ProteomicsThe role and mechanism of TRPV1 SUMOylation in inhibiting the proliferation and migration of gastric cancer cells
In this work, we elucidate a novel mechanism wherein TRPV1 SUMOylation promotes its membrane expression and activates the TRPV1-Ca2+-AMPK signaling pathway, thereby inhibiting GC cell proliferation and migration. These findings enhance our understanding of the molecular dynamics in gastric cancer an...
ORGANISM(S): Mus Musculus 
2024-03-25 | PXD050941 |
ProteomicsSUMOylation-Induced Membrane Localization of TRPV1 Suppresses Proliferation and Migration in Gastric Cancer Cells
In this work, we elucidate a novel mechanism wherein TRPV1 SUMOylation promotes its membrane expression and activates the TRPV1-Ca2+-AMPK signaling pathway, thereby inhibiting GC cell proliferation and migration. These findings enhance our understanding of the molecular dynamics in gastric cancer an...
ORGANISM(S): Homo Sapiens 
2024-03-25 | PXD050942 |
ProteomicsDIA proteomics analysis of mice in models of myocardial infarction and heart failure with preserved ejection fraction (HFpEF).
The dataset includes two parts: a) Proteomics of mouse heart tissue 14 days after myocardial infarction and long-term exercised mice post-myocardial infarction for 14 days; b) Cardiac proteomics of a model of heart failure with preserved ejection fraction (HFpEF) induced by L-NAME and high-fat diet-...
ORGANISM(S): Mus Musculus 
PXD051242 |
ProteomicsProteomics analysis report of esophageal squamous cell carcinoma treated by Dasabuvir
In order to detect the effect of Dasabuvir on the protein expression of esophageal cancer cells, we used control and drug-added KYSE150 cells for proteomic analysis
ORGANISM(S): Homo Sapiens 
2022-01-24 | PXD031186 |
ProteomicsEndothelial FGF13 impairs angiogenesis by accelerating oxygen-independent HIF-1α degradation
Anti-Flag antibody was added to the lysate of HUVECs transfected with Flag-FGF13 for co-immunoprecipitation, and IgG was used as a negative control. LC-MS/MS analysis was carried out by PTM Bio Co., Ltd (Zhejiang, China). The substrate proteins that may bind to FGF13 were screened out according to t...
ORGANISM(S): Homo Sapiens 
PXD079802 |
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