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UnknownFerroptosis's Master Switch GPX4 emerges as universal biomarker for precision immunotherapy: a pan-cancer study with <i>in vitro</i> experiments validation.
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S-EPMC12545133 | biostudies-literature
MetabolomicsDifferent regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly
Vesicle associated membrane protein 2 (VAMP2/synaptobrevin2), a core SNARE protein residing on synaptic vesicles (SVs), forms helix bundles with syntaxin-1 and SNAP25 for the SNARE assembly. Prior to the SNARE assembly, the structure of VAMP2 is unclear. Here, by using in-cell NMR spectroscopy, we d...
2021-10-06 | MTBLS1503 | MetaboLights
ProteomicsProteomic analysis of linear ubiquitination substrates based on NAEK-Ub probe in live cells
While linear ubiquitin plays critical roles in multiple cell signaling pathways, few substrates have been identified. Global profiling of linear ubiquitin substrates represents a significant challenge because of the low endogenous level of linear ubiquitination, the none-specific binding of linear p...
ORGANISM(S): Homo Sapiens 
2022-02-11 | PXD031600 |
ProteomicsMapping novel biomarkers of liver injury by tissue proteomic analysis
Liver damage is a dynamic process and evaluation of liver injury degree is the key step in disease diagnose. However, few common markers between different types of liver injury have been reported. Herein, we generate three liver injury mouse models including Con A induced, CCl4 injected and subjecte...
ORGANISM(S): Mus Musculus 
2020-11-25 | PXD022716 |
ProteomicsO-GlcNAcylation Promotes Cerebellum Development and Medulloblastoma Oncogenesis via SHH Signaling
Sonic hedgehog (Shh) signaling plays a critical role in regulating cerebellum development by maintaining the physiological proliferation of granule neuron precursors (GNPs), and its dysregulation leads to the oncogenesis of medulloblastoma. O-GlcNAcylation (O-GlcNAc) of proteins is an emerging regul...
ORGANISM(S): Homo Sapiens 
2022-06-02 | PXD034270 |
ProteomicsLabel-free quantitative proteomic analysis for normal and inflamed colonic mucosa from patients with ulcerative colitis
Label-free quantitative proteomic analysis for clinical tissues of 5 normal and 5 inflamed colonic mucosa. The EASY-nLC 1200 system and Q Exactive Plus were used for peptides detection. A total of 4102 proteins were identified, and 2713 proteins were quantified. According to the criterion fold chang...
ORGANISM(S): Homo Sapiens 
2025-03-12 | PXD061745 |
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