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MetabolomicsRisk assessment with gut microbiome and metabolite markers in NAFLD development
A growing body of evidence suggests interplay between the gut microbiota and the pathogenesis of nonalcoholic fatty liver disease (NAFLD). However, the role of the gut microbiome in early detection of NAFLD is unclear. Prospective studies are necessary for identifying reliable, microbiome markers fo...
2022-07-11 | MTBLS2615 | MetaboLights
UnknownEight Mutations of Three Genes (EDA, EDAR, and WNT10A) Identified in Seven Hypohidrotic Ectodermal Dysplasia Patients.
Not available
S-EPMC5042395 | biostudies-literature
TranscriptomicsRNA-seq analysis of crypt samples isolated from the small intestine of Bach2 KO and control mice
Epithelial regeneration is critical for barrier maintenance and organ function after intestinal injury. Here, we found that Bach2 deficiency promotes the intestinal epithelial cell proliferation during homeostasis and facilitates the crypt regeneration after irradiation, resulting in a reduction of ...
ORGANISM(S): Mus musculus 
2021-01-12 | E-MTAB-9865 | biostudies-arrayexpress
MetabolomicsAberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents

OBJECTIVE: Patients with renal failure suffer from symptoms caused by uraemic toxins, possibly of gut microbial origin, as deduced from studies in animals. The aim of the study is to characterise relationships between the intestinal microbiome composition, uraemic toxins and rena...

2020-10-20 | MTBLS700 | MetaboLights
ProteomicsLeucine catabolic enzyme AUH regulates brown fat thermogenesis through HMGylation of PPARγ and RNA-binding function in male mice
A strong association between leucine and obesity has been well established; however, the role of leucine catabolic enzymes in adipose tissue remains largely unknown. Here, we show that knockdown of the leucine catabolic enzyme AU RNA binding methylglutaconyl-CoA hydratase (AUH) in brown adipocytes r...
ORGANISM(S): Mus Musculus 
2026-03-09 | PXD075390 |
ProteomicsShiga toxin 2a induces mitochondrial damage, mitophagy and apoptosis via the interaction of Tom20 in Caco-2 cells
Shiga toxin type 2 (Stx2) is the main virulence factor produced by Stx-producing Escherichia coli (STEC) responsible for hemorrhagic colitis and the life-threatening sequela hemolytic uremic syndrome.
ORGANISM(S): Homo Sapiens 
2022-11-21 | PXD038256 |
ProteomicsExploring the interaction proteins of Sub1 in aging cardiomyocytes by protein MS
After transferring the Sub1 Flag plasmid into HL-1 cells, the cells were treated with bleomycin for 24 hours, followed by immunoprecipitation using Flag magnetic beads and protein mass spectrometry.
ORGANISM(S): Mus Musculus 
PXD080102 |
ProteomicsMass spec results of Tmc7-GST pull-down
For the GST pull-down of DRG ganglion, the GST- or Tmc7-GST-associated beads were further incubated with cell lysates derived from DRG ganglion. The pulled-down proteins were then separated by SDS-PAGE gel electrophoresis and subsequently stained with silver staining Kit. Finally, the target molecul...
ORGANISM(S): Mus Musculus 
2024-03-08 | PXD050466 |
ProteomicsSerum proteomics of individuals with MASLD under resistance starch intervention
Searching for baseline proteins that contribute to the individual response to RS intervention
ORGANISM(S): Homo Sapiens 
PXD068798 |
ProteomicsProteomics and Human Microchips Identify Thrombospondin-1 as a Potential Biomarker for Calciphylaxis Stem Cell Therapy
Calciphylaxis, also known as calcific uremic arteriolopathy (CUA), is a rare disease with high mortality rate. We effectively rescued CUA patients with novel human amnion-derived mesenchymal stem cell (hAMSC) therapy. Due to the heterogeneity of cutaneous lesion, it is imperative to identify non-inv...
ORGANISM(S): Homo Sapiens 
PXD078388 |
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