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ProteomicsMulti-Omics and Machine Learning-Based Profiling of Severity Signatures in Mycoplasma Pneumoniae Infection in Children
Mycoplasma pneumoniae pneumonia (MPP) is a common respiratory infection in children, yet the mechanisms driving its progression to severe disease remain poorly understood. This study employs a comprehensive proteomic and metabolomic approach to elucidate severity-related pathways and identify potent...
ORGANISM(S): Homo sapiens (Human) 
2025-12-12 | PXD063022 | Pride
ProteomicsMulti-Omics and Machine Learning-Based Profiling of Severity Signatures in Mycoplasma Pneumoniae Infection in Children
Mycoplasma pneumoniae pneumonia (MPP) is a common respiratory infection in children, yet the mechanisms driving its progression to severe disease remain poorly understood. This study employs a comprehensive proteomic and metabolomic approach to elucidate severity-related pathways and identify potent...
ORGANISM(S): Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
2025-12-12 | PXD071661 | Pride
Machine learning Pediatrics infection Mycoplasma pneumoniae Multi-omics Severity signatures 
ProteomicsProteomic analysis identified age-associated prognostic biomarkers in pneumonia-derived pediatric sepsis
Pediatric sepsis is a leading cause of mortality in children across the world. Within pediatric sepsis, how developmental age-specific host immune response impact on the occurrence and development of pediatric sepsis is still unknown, especially between infants and toddlers, which were the major sus...
ORGANISM(S): Homo sapiens (Human) 
2021-11-01 | PXD026656 | Pride
Pediatric sepsis Picu 
ProteomicsProteomic, phosphoproteomic and N-glycoproteomic analysis of small extracellular vesicles (sEVs) from C2C12 myoblasts
We conducted a comprehensive and integrated proteomic，phosphoproteomic, N-glycoproteomic analysis of the cargos in small extracellular vesicles (sEVs)-derived from C2C12 myoblasts.
ORGANISM(S): Mus Musculus 
2023-12-20 | PXD047974 |
ProteomicsComprehensive evaluation of different TiO2-based phosphopeptide enrichment and fractionation methods for phosphoproteomics
We performed a comprehensive evaluation of four different TiO2-based phosphopeptide enrichment methods using different non-phosphopeptide excluders. Then, two phosphopeptide fractionation methods, including the ammonia-based and the TEA based high pH reversed-phase fractionation, are also evaluated.
ORGANISM(S): Homo Sapiens 
2022-06-02 | PXD034264 |
ProteomicsSNX10 regulates the proliferation, apoptosis and cell cycle of acute B lymphoblastic leukemia cells via the PI3K/Akt signaling pathway
B-cell acute lymphoblastic leukemia (B-ALL) is a type of acute lymphoblastic leukemia that originates from B cells. It typically occurs in children and adolescents, but it can also appear in adults. Sorting nexin 10 (SNX10) has recently been identified as a significant regulatory factor in various t...
ORGANISM(S): Homo Sapiens 
2025-03-14 | PXD061830 |
ProteomicsAn ITRAQ-Based Quantitative Proteomics Analysis of the Hepatoprotective Effect of Melatonin on ANIT-Induced Cholestasis in Rats.
The aim of the present study was to investigate the therapeutic mechanism of the anti-cholestatic effects of melatonin against ANIT-induced liver injury in rats, and to screen for potential biomarkers of cholestasis through isobaric tags for relative and absolute quantitation (iTRAQ) quantitative pr...
ORGANISM(S): Rattus Norvegicus 
2020-12-16 | PXD023155 |
ProteomicsPlasma proteome profiling combined with clinical and genetic features reveals pathophysiological characteristics of β-thalassemia
The phenotype of β-thalassemia underlies multigene interactions, making clinical stratification complicated. An increasing number of genetic modifiers affecting the disease severity have been identified, but are still unable to meet the demand of precision diagnosis. Here, we systematically conducte...
ORGANISM(S): Homo Sapiens 
2022-03-10 | PXD032179 |
Proteomicsβ-thalassemia plasma EVs proteomics
Here, we performed plasma extracellular vesicles (EVs) proteomics on 20 β-thalassemia major (TM) patients, 20 intermedia (TI) patients, and 20 healthy controls to explore the subgroup characteristics and the potential biomarkers. The proteome of paired plasma was analyzed in parallel to compare the ...
ORGANISM(S): Homo Sapiens 
2022-06-15 | PXD034548 |
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