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TranscriptomicsA Highly Sensitive and Unbiased Approach for Elucidating Antibody Repertoires
Developing B lymphocytes undergo V(D)J recombination to assemble germline V, D, and J gene segments into exons that encode the antigen-binding variable region of immunoglobulin (Ig) heavy (H) and light (L) chains. IgH and IgL chains associate to form the B cell receptor (BCR), which upon antigen bi...
ORGANISM(S): Mus musculus 
2016-07-22 | E-GEOD-82126 | biostudies-arrayexpress
TranscriptomicsHigh-Low Fat Diet/Strain Experiment
Males and females from each SM/J and LG/J were placed on either a low-fat diet or high-fat diet immediately after weaning until 20 weeks of age. At 20 weeks, mice were sacrificed in late morning after a four-hour fast and liver tissue was collected from 4 males and 4 females from each strain and die...
ORGANISM(S): Mus musculus 
2014-01-30 | E-MTAB-2172 | biostudies-arrayexpress
TranscriptomicsDietary folate depletion and repletion in A/J and C57BL/6J mice
Defects in homocysteine and folate metabolism are associated with increased risks for neural tube and congenital heart defects, cardiovascular disease and stroke, cancers, and neurodegeneration. In many but not all cases, dietary supplementation with folate significantly reduces the severity and in...
ORGANISM(S): Mus musculus 
2008-08-27 | E-GEOD-9242 | biostudies-arrayexpress
GenomicsMouse spleen: Histone modification patterns in spleens from wild type and leukemic mice
ChIP-Seq for H3K4me3 and H3K27me3 in wild type spleens and spleens from mice having deletion of RBP-J in cells of the renin lineage, which results in B-cell leukemia. Examination of 2 different histone modifications in wild type and mutant spleens.
ORGANISM(S): Mus musculus 
2014-02-17 | E-GEOD-46566 | biostudies-arrayexpress
TranscriptomicsCardiac left ventricles of 12 week-old male C57BL/6J and C57BL/6J-chrY mice
We have reported previously that when chromosome Y (chrY) from the mouse strain C57BL/6J (abbreviated as B) was substituted for that of A/J mice (ChrY), cardiomyocytes from the resulting 'chromosome substitution' C57BL/6J-chrY strain (abbreviated as B.Y) were smaller than that of their C57BL/6...
ORGANISM(S): Mus musculus 
2009-05-01 | E-GEOD-15354 | biostudies-arrayexpress
TranscriptomicsOrientation-Specific Joining of AID-initiated DNA Breaks Promotes Antibody Class Switching
During B cell development, RAG endonuclease cleaves immunoglobulin heavy chain (IgH) V, D, and J gene segments and orchestrates their fusion as deletional events that assemble a V(D)J exon in the same transcriptional orientation as adjacent Cμ constant region exons. In mice, six additional sets of c...
ORGANISM(S): Mus musculus 
2015-08-26 | E-GEOD-71005 | biostudies-arrayexpress
TranscriptomicsExpression data comparing human DKK1 and control vector transfected murine osteochondrosarcoma cells (MOS-J)
Canonical Wnt signaling controls proliferation and differentiation of osteogenic progenitor cells, and tumor-derived secretion of the Wnt antagonist Dickkopf-1 (Dkk1) is correlated with osteolyses and metastasis in many bone malignancies. However, the role of Dkk1 in the oncogenesis of primary osteo...
ORGANISM(S): Mus musculus 
2012-12-22 | E-GEOD-43112 | biostudies-arrayexpress
TranscriptomicsSolar simulated ultraviolet radiation induces histone 3 methylation changes in the gene promoters of matrix metalloproteinases 1 and 3 in primary human dermal fibroblasts [I]
Skin damage from solar ultraviolet radiation (UVR) accumulates in the dermal extracellular matrix (ECM) and contributes to photoaging. Following UVR exposure, matrix metalloproteinases (MMPs) are secreted by dermal fibroblasts to repair and remodel the ECM. Molecular signaling pathways delineating t...
ORGANISM(S): Homo sapiens 
2014-08-27 | E-GEOD-60794 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse lung from C57BL/6J and A/J mice during embryonic development
In this study, time dependent genome wide lung mRNA profiling changes were assessed using C57BL/6J and A/J mice. Through comprehensive bioinformatics and functional genomics analyses, we identified both temporal and strain dependent gene expression patterns, systemically mapped key regulators, biopr...
ORGANISM(S): Mus musculus 
2012-07-30 | E-GEOD-35485 | biostudies-arrayexpress
TranscriptomicsComparison of the gene expression profiles between iPS-OSH, iPS-J, ESC and MEF.
iPS-OSH was the novel iPS cells generated from our lab, the microarray analysis was used for determining the gene expression profiles of iPS-OSH. iPS-J was provided from Dr. Yamanaka (Riken, APS0001). Microarray analysis was used to compare the difference of gene expression profiles in iPS-OSH, iPS-...
ORGANISM(S): Mus musculus 
2012-07-31 | E-GEOD-31822 | biostudies-arrayexpress
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