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MetabolomicsEvidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure

INTRODUCTION: Myxomatous mitral valve disease (MMVD) is the most common cardiac condition in adult dogs. The disease progresses over several years and affected dogs may develop congestive heart failure (HF). Research has shown that myocardial metabolism is altered in cardiac dise...

2022-03-31 | MTBLS716 | MetaboLights
TranscriptomicsRNAseq of small intestinal organoids from mice treated with the cytokines IL-13 and IL-22 for 72 hours in combination with the BMP signaling inhibitor DMH1
The intestinal epithelium is our first line of defense against infections of the gut and the plasticity in cellular differentiation of the intestinal epithelium is an important part of this response. The changes in cellular composition is driven by immune cell derived cytokines. Here we use signatur...
ORGANISM(S): Mus musculus 
2022-05-08 | E-MTAB-9185 | biostudies-arrayexpress
UnknownPublic Perceptions of Physician Attire and Professionalism in the US.
Not available
S-EPMC8325071 | biostudies-literature
UnknownCDK12-inactivation-induced MYC signaling causes dependency on the splicing kinase SRPK1.
Not available
S-EPMC11459032 | biostudies-literature
ProteomicsDefining enteric bacterial pathogenesis using organoids: Citrobacter rodentium uses EspC, an atypical mucinolytic protease, to penetrate mouse colonic mucus
Enteric bacterial pathogens pose significant threats to human health; however, the mechanisms by which they infect the mammalian gut in the face of daunting host defenses remain to be fully defined. For the attaching and effacing (A/E) bacterial family member and murine pathogen Citrobacter rodentiu...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-17 | PXD061145 | Pride
Espc Mucus Air-liquid interface Colonoids Enteric pathogens 
UnknownCompromised CDK12 activity causes dependency on the high activity of O-GlcNAc transferase.
Not available
S-EPMC11632362 | biostudies-literature
TranscriptomicsTranscription profiling by array of wheat and barley to anchor physical and genetic maps in wheat using a barley array
Background Because of its size, allohexaploid nature and high repeat content, the wheat genome has always been perceived as too complex for efficient molecular studies. However, we recently constructed the first physical map of a wheat chromosome (3B). But gene mapping is still laborious in wheat be...
ORGANISM(S): Hordeum vulgare 
2010-12-02 | E-TABM-1011 | biostudies-arrayexpress
Genomicsβ-catenin regulates primitive streak induction through collaborative interactions with SMAD2/3 and OCT4
Canonical Wnt and Nodal signaling are both required for induction of the primitive streak (PS), which guides organization of the early embryo. The Wnt effector β-catenin is thought to function in these early lineage specification decisions via transcriptional activation of Nodal signaling. Here, we ...
ORGANISM(S): Homo sapiens 
2015-03-31 | E-GEOD-58476 | biostudies-arrayexpress
TranscriptomicsCpG islands Methylation Profiling by DMH in Epithelial Ovarian Cancer: Screening Set
We have systematically profiled DNA methylation at promoter CpG islands (CGIs) in ovarian cancer. Epithelial ovarian tumours, excluding mucinous and clear cell cancers, prospectively collected through a cohort study, were analyzed by differential methylation hybridization (DMH) (Nouzova M et al, 200...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-23240 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation analysis reveals dynamic changes in the cardiac methylome during post-natal heart development (RNA-Seq)
Epigenetic modifications have emerged as central players in the coordination of gene expression networks during cardiac development. While several studies have investigated the role of histone modifications during heart development, relatively little is known about the role of DNA methylation. The p...
ORGANISM(S): Mus musculus 
2014-08-01 | E-GEOD-59970 | biostudies-arrayexpress
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