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ProteomicsVHL synthetic lethality screens uncover CBF-β as a negative regulator of STING.
Clear cell renal cell carcinoma (ccRCC) represents the most common form of kidney cancer and is typified by biallelic inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene. Here, we undertake genome-wide CRISPR/Cas9 screening to reveal synthetic lethal interactors of VHL, and uncover th...
ORGANISM(S): Homo sapiens (Human) 
2026-02-13 | PXD074426 | Pride
Sting Cbf-β Vhl Clear cell renal cell carcinoma Type i interferon 
TranscriptomicsTranscription profiling of maize segmental aneuploid to study phenotypic and gene expression changes associated with aneuploidy
ABSTRACT: BACKGROUND: While changes in chromosome number that result in aneuploidy are associated with phenotypic consequences such as Down syndrome and cancer, the molecular causes of specific phenotypes and genome-wide expression changes that occur in aneuploids are still being elucidated. RESULTS...
ORGANISM(S): Zea mays 
2008-06-11 | E-GEOD-10243 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Jurkat T leukemia cells to detect anticancer metabolites discovered by computational metabolomics
CoMet, a fully automated Computational Metabolomics method to predict changes in metabolite levels in cancer cells compared to normal references has been developed and applied to Jurkat T leukemia cells with the goal of testing the following hypothesis: up or down regulation in cancer cells of the e...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-9648 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of maize inbred lines B73 and Mo17
Microarray analysis of gene expression patterns in immature ear, seedling, and embryo tissues from the maize inbred lines B73 and Mo17 identified numerous genes with variable expression. Some genes had detectable expression in only one of the two inbreds; most of these genes were detected in the gen...
ORGANISM(S): Zea mays 
2008-06-16 | E-GEOD-8176 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of maize inbred lines B73 and Mo17 leads to additive expression - seedling data
Microarray analysis of gene expression patterns in immature ear, seedling, and embryo tissues from the maize inbred lines B73 and Mo17 identified numerous genes with variable expression. Some genes had detectable expression in only one of the two inbreds; most of these genes were detected in the gen...
ORGANISM(S): Zea mays 
2008-06-17 | E-GEOD-8174 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of maize inbred lines
This SuperSeries is composed of the following subset Series:; GSE8174: Cis-transcriptional variation in maize inbred lines B73 and Mo17 leads to additive expression - Seedling data; GSE8176: Cis-transcriptional variation in maize inbred lines B73 and Mo17 leads to additive expression - Immature ear ...
ORGANISM(S): Zea mays 
2008-06-17 | E-GEOD-8194 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mazie inbred lines B73 and Mo17 leads to additive expression - Embryo data
Microarray analysis of gene expression patterns in immature ear, seedling, and embryo tissues from the maize inbred lines B73 and Mo17 identified numerous genes with variable expression. Some genes had detectable expression in only one of the two inbreds; most of these genes were detected in the gen...
ORGANISM(S): Zea mays 
2008-06-16 | E-GEOD-8179 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of maize non-additive and imprinted gene expression in endosperm_13DAP and 19DAP
This SuperSeries is composed of the following subset Series:; GSE8275: Non-additive and imprinted gene expression in hybrid maize endosperm_13DAP; GSE8278: Non-additive and imprinted gene expression in hybrid maize endosperm_19DAP Experiment Overall Design: Refer to individual Series
ORGANISM(S): Zea mays 
2008-06-16 | E-GEOD-8308 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of maize endosperm tissues from inbred lines B73 and Mo17 and their reciprocal hybrids at two developmental stages, 13 and 19 days after pollination to determine non-additive and imprinted gene expressionP
The nuclear content of the plant endosperm is the result of the contribution two maternal genomes and a single paternal genome. This 2:1 dosage relationship provides a unique system for studying the additivity of gene expression levels in reciprocal hybrids. A combination of microarray profiling a...
ORGANISM(S): Zea mays 
2008-06-16 | E-GEOD-8275 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of maize endoderm from plants 17 days after pollination in Genotype: B73 and Mo17 hybrids
The nuclear content of the plant endosperm is the result of the contribution two maternal genomes and a single paternal genome. This 2:1 dosage relationship provides a unique system for studying the additivity of gene expression levels in reciprocal hybrids. A combination of microarray profiling a...
ORGANISM(S): Zea mays 
2008-06-16 | E-GEOD-8278 | biostudies-arrayexpress
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