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ProteomicsSystematic proteomics analysis of lysine acetylation reveals critical features of renal proteins in kidney calculi formation
In this study, we systematically integrated proteome and acetyl proteome (acetylome) approaches to investigate the characteristics of renal proteins in a CaOx crystal rat model. We aimed to understand the pathogenesis of kidney calculi and delineate the landscape of acetylation within kidney calculi...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-02-09 | PXD050342 | Pride
Kidney calculi  acetylation  proteomics 
UnknownComplete mitochondrial genome of Hippophae tibetana: insights into adaptation to high-altitude environments.
Not available
S-EPMC11335646 | biostudies-literature
ProteomicsAndrogen Rapidly Activates Phosphorylation Signaling Pathways in Sertoli Cells
This study comprehensively analyzed androgen-activated phosphorylation signaling pathways in testicular Sertoli cells. Primary cultured mouse Sertoli cells were treated with testosterone for varying durations. Using Tandem Mass Tag (TMT)-labeled phosphoproteomics technology combined with Mfuzz clust...
ORGANISM(S): Mus Musculus 
2026-05-20 | PXD078604 |
UnknownEfficacy and Tolerability of First-Line Cetuximab Plus Leucovorin, Fluorouracil, and Oxaliplatin (FOLFOX-4) Versus FOLFOX-4 in Patients With RAS Wild-Type Metastatic Colorectal Cancer: The Open-Label, Randomized, Phase III TAILOR Trial.
Not available
S-EPMC6324088 | biostudies-literature
UnknownIntegrated transcriptome and metabolome analysis of melanin-related genes and metabolites in Muchuan Black Bones Chickens.
Not available
S-EPMC12752978 | biostudies-literature
ProteomicsTreachery of hepatic protector triggers Notch signaling to promote hepatocyte-originated cholangiocarcinoma
Here, we found mesencephalic astrocyte-derived neurotrophic factor (MANF), a hepatic protector, was upregulated in human ICC tissues and sleeping beauty transposon (SBT) or thioacetamide (TAA)-induced mice ICC tissues. We verified the oncogenic role of MANF in ICC using cell lines overexpressing/kno...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD048451 | Pride
Hepatocytes Ip-ms Hucct1 Notch Cholangiocarcinoma Ck19 
GenomicsHigh density copy number analysis and whole exome sequencing of diffuse large B-cell lymphoma

Diffuse Large B-cell Lymphoma (DLBCL) represents the most common form of B-cell non-Hodgkin Lymphoma (B-NHL), accounting for ~30% of the de-novo diagnoses and also arising as a frequent clinical evolution of Follicular Lymphoma (FL). The molecular pathogenesis of DLBCL is associated with multip...

phs000328.v1.p1 | EGA
TranscriptomicsPCGF6, a polycomb group protein, regulates mesodermal lineage differentiation in murine ES cells and functions in iPS reprogramming
Polycomb group (PcG) proteins comprise a large group of evolutionary conserved factors with essential roles for embryonic development and adult stem cell function. PcG proteins constitute two main multiprotein polycomb repressive complexes (PRC1 and PRC2) that operate in a hierarchical manner to sil...
ORGANISM(S): Mus musculus 
2014-09-26 | E-GEOD-56126 | biostudies-arrayexpress
TranscriptomicsDynamic Gene Expression Response to TGF-b Stimulation in Multipotent Progenitors and Common Dendritic Cell Progenitors
Multipotent progenitors (MPP) and common dendritic cell progenitors (CDP) were obtained from mouse bone marrow, followed by in vitro culture with a specific cytokine cocktail and FACS sorting (Felker et al., 2010; Sere et al., 2012). Cells were treated with 10 ng/ml recombinant human TGF-b1 (R&D Sys...
ORGANISM(S): Mus musculus 
2014-04-15 | E-GEOD-46109 | biostudies-arrayexpress
ProteomicsCleavable Hydrophobic Derivatization Strategy for Enrichment and Identification of Phosphorylated Lysine Peptides
Herein, a cleavable hydrophobic derivatization (CHD) strategy was established for the enrichment and identification of pLys peptides. By CHD, 2,5-dioxopyrrolidin-1-yl-3-(decyldisulfanyl)propanoate (Dec-disulf-NHS) was synthesized to react with lysine dephosphorylated peptides, and then the derived p...
ORGANISM(S): Escherichia Coli 
2019-02-12 | PXD012682 |
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