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ProteomicsAIM2 in regulatory T (Treg) cells restrains autoimmune diseases
The inflammasome initiates innate defense and inflammatory response by activating caspase-1 and pyroptotic cell death in myeloid cells1,2. It is comprised of an innate immune receptor/effector, pro-caspase-1 and a common adaptor molecule, ASC (apoptotic speck-containing protein with a CARD). Consis...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-27 | PXD018638 | Pride
Autoimmunity Aim2 (absent in melanoma 2) Akt-mtor signaling 
UnknownExperimental Study on the Modified P-V-T Model to Improve Shrinkage Prediction for Injection-Molded Semi-Crystalline Polymer.
Not available
S-EPMC12899455 | biostudies-literature
UnknownDevelopment and validation of a 16-gene T-cell- related prognostic model in non-small cell lung cancer.
Not available
S-EPMC12009871 | biostudies-literature
TranscriptomicsIdentifying the genes involved in CD4+ T cell mediated-acute allograft rejection
Acute allograft rejection is a leading cause for the failure of organ allotransplantation. Identifying the genes involved in the rejection process provides clues to study the mechanisms, and to provide specific gene targets for monitoring, predicting and preventing acute allograft rejection. Using a...
ORGANISM(S): Mus musculus 
2010-02-28 | E-GEOD-14540 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of pancreas from rats of four strains after drinking ethanol at various concentrations for twelve months
Male rats from one of four strains (Wistar, AA, HAD or P) were housed individually in standard hanging rodent cages (Ehret, Emmendingen, Germany) on a 12-hour light-dark cycle with lights on at 07:00 a.m.. Animals were provided with food (Sniff, Soest, Germany), tap water, 5, 10 and 20% (v/v) ethano...
ORGANISM(S): Rattus norvegicus 
2009-12-31 | E-MEXP-776 | biostudies-arrayexpress
TranscriptomicsMicroRNA analysis unravels the molecular basis of bleomycin induced lung fibrosis in mouse
The molecular mechanisms of lung injury and fibrosis are incompletely understood. microRNAs (miRNAs) are crucial biological regulators by suppression of their target genes and are involved in a variety of pathophysiologic processes. To gain insight into miRNAs in the regulation of lung fibrosis, tot...
ORGANISM(S): Mus musculus 
2012-04-12 | E-GEOD-24323 | biostudies-arrayexpress
UnknownAIM2 in regulatory T cells restrains autoimmune diseases.
Not available
S-EPMC8080937 | biostudies-literature
Proteomicsstreptococcus suis LC-MS/MS - MnmE, a Central tRNA-Modifying GTPase, Is Essential for the Growth, Pathogenicity, and Arginine Metabolism of Streptococcus suis Serotype 2
Streptococcus suis is an important pathogen in pigs and can also cause severe infections in humans. However, little is known about proteins associated with cell growth and virulence of S. suis. In this study, a GTPase MnmE homologue was identified in a Chinese isolate (SC19) that drives a tRNA modif...
ORGANISM(S): Streptococcus suis SC149 
2019-11-13 | PXD012716 | Pride
Ss2 Tmt Mnme 
TranscriptomicsMiRNA-127 Inhibits IgG Immune Complex-induced Lung Inflammation by Targeting IgG Fcγ Receptor I
The molecular mechanisms of acute lung injury are incompletely understood. MicroRNAs (miRNAs) are crucial biological regulators that act by suppressing their target genes and are involved in a variety of pathophysiologic processes. MiR-127 appeared to be down-regulated during lung injury. We set out...
ORGANISM(S): Mus musculus 
2012-04-03 | E-GEOD-27642 | biostudies-arrayexpress
TranscriptomicsIdentification of the gene expression in IPF lung fibroblasts after demethylation
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease. Although the pathogenesis is poorly understood, evidence suggests that genetic and epigenetic alterations, such as DNA methylation, may play a key role. We used microarrays to see the gene expression in IPF fibroblasts after demethyl...
ORGANISM(S): Homo sapiens 
2016-02-16 | E-GEOD-69764 | biostudies-arrayexpress
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