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TranscriptomicsEffects of ONC201 on mantle cell lymphoma cell lines
The small molecule ONC201 is toxic in vitro to multiple cell lines and primary tumor samples of mantle cell lymphoma (MCL) and acute myeloid leukemia, even ones with unfavorable genetic features (notably including TP53 inactivation) or acquired resistance to other agents. Because the mechanism of ac...
ORGANISM(S): Homo sapiens 
2016-02-20 | E-GEOD-68091 | biostudies-arrayexpress
ProteomicsQuantitative Proteomic Analysis of buffalo ovaries
The ovary is the most important sexual organ of female mammals, and its corpus luteum plays a significant role in mammalian reproduction during the estrus cycle. Here we conducted a quantitative proteomic analysis using tandem mass tag (TMT)-labeling coupled with Nano-LC-MS/MS to explore the mechani...
ORGANISM(S): Bubalus Bubalis 
2019-10-30 | PXD016072 |
ProteomicsMulti-omics analysis reveals regulatory networks of pattern-triggered immunity in rice
we performed multi-omics analysis to determine how rice PTI response to chitin and flg22. we integrated metablomics, transcriptomics, proteomics.
ORGANISM(S): Oryza Sativa 
2021-04-21 | PXD025565 |
ProteomicseIF4E2 regulates GSK3b kinase activity
we found eIF4E2 regulates GSK3b kinase activity. And we performed the quantitative iTRAQ-based phosphoproteomic to identify phophosites regulated by eIF4E2-GSK3b pathway
ORGANISM(S): Homo Sapiens 
2021-02-17 | PXD024226 |
ProteomicsIdentification of proteins affected by PTENα under stress conditions by mass spectrometry
Stress granules are known to be related with selective translation. To determine which proteins are regulated by stress granules assembly in Ptenα─/─ MEFs, we performed a mass spectrometry analysis of Ptenα+/+ and Ptenα─/─ MEFs under oxidative stress.
ORGANISM(S): Mus Musculus 
2020-10-03 | PXD021840 |
ProteomicsIdentification of PTENα associated proteins under stress condictions in B16 cells by mass spectrometry
PTENα is the first isoform of tumor suppressor PTEN. To investigate the molecular mechanism by which PTENα modulates cell response to inflammation, we performed pull-down assays with FLAG-tagged proteins coupled with mass spectrometry under condition of H2O2 treatment in B16 cells.
ORGANISM(S): Mus Musculus 
2021-07-13 | PXD040709 |
ProteomicsiTRAQ proteomics reveals the regulatory response to Magnaporthe oryzae in durable resistant vs. susceptible rice genotypes
Here, we used the iTRAQ method to detect the differentially expressed proteins (DEPs) in the durable resistant rice variety Gangyuan8 (GY8) and the susceptible rice variety Lijiangxintuanheigu (LTH) in response to M. oryzae invasion, and then transcriptome sequencing was used to assist analysisA tot...
ORGANISM(S): Oryza Sativa 
2019-12-09 | PXD016645 |
GenomicsPi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival [ChIPseq]
Background—YAP, the nuclear effector of Hippo signaling, regulates cellular growth and survival in multiple organs, including the heart, by interacting with TEAD sequence specific DNA-binding proteins. Recent studies showed that YAP stimulates cardiomyocyte proliferation and survival. However, the d...
ORGANISM(S): Mus musculus 
2015-02-20 | E-GEOD-57717 | biostudies-arrayexpress
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