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ProteomicsTemozolomide Induces Glioblastoma Dedifferentiation into Highly Malignant Stem-like Cells Through Senescence-Associated Reprogramming via HIF1α/HIF2α Regulation
A critical issue is that recurrent glioblastoma multiforme (GBM) after temozolomide (TMZ) exposure becomes more malignant, exhibiting higher invasion and stemness than the primary tumor. However, the detailed mechanism remains to be elucidated. While the majority of GBM cells succumb to TMZ treatmen...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058156 | Pride
Temozolomide Glioblastoma 
TranscriptomicsThe yeast osmostress response is carbon source dependent
Adaptation to altered osmotic conditions is a fundamental property of living cells and has been studied in particular detail in the yeast Saccharomyces cerevisiae. Yeast cells accumulate glycerol as compatible solute, controlled at different levels by the High Osmolarity Glycerol (HOG) response path...
ORGANISM(S): Saccharomyces cerevisiae 
2017-02-27 | E-MTAB-5313 | biostudies-arrayexpress
MetabolomicsAlterations in the Gut Microbiota and Metabolomics of Seafarers after a Six-Month Sea Voyage

Maintaining the health of seafarers is a difficult task during long-term voyages. Little is known about the corresponding changes in the gut microbiome-host interaction. This study recruited 30 seafarers undertaking a 6-month voyage and analyzed their gut microbiota using 16S rRNA gene sequencing...

2022-09-29 | MTBLS5335 | MetaboLights
UnknownGABA signaling enforces intestinal germinal center B cell differentiation.
Not available
S-EPMC9636909 | biostudies-literature
TranscriptomicsThe transcriptional modulator H2AFY marks Huntington's disease activity in men and mice
To accelerate the development of disease-modifying therapeutics for Huntington’s disease (HD), a dynamic biomarker of disease activity and treatment response is critically needed. Venous cellular whole blood from 8 patients with Huntington's disease (HD) and 6 control subjects were collected in PAXg...
ORGANISM(S): Homo sapiens 
2011-09-01 | E-GEOD-24250 | biostudies-arrayexpress
UnknownCircRNA EPHB4 modulates stem properties and proliferation of gliomas via sponging miR-637 and up-regulating SOX10.
Not available
S-EPMC7858283 | biostudies-literature
UnknownMicroRNA-106b-5p inhibits growth and progression of lung adenocarcinoma cells by downregulating IGSF10.
Not available
S-EPMC8351668 | biostudies-literature
UnknownSirt1-inducible deacetylation of p21 promotes cardiomyocyte proliferation.
Not available
S-EPMC6949046 | biostudies-literature
UnknownThe complete mitochondrial genome of the Anas platyrhynchos Linnaeus, 1758 breed Longshengcui and its phylogenetic analyses.
Not available
S-EPMC10405745 | biostudies-literature
ProteomicsQuantitative Khib proteomic analyses of 20 cases of primary ESCC tumor tissue (T), matched normal tissue (N) and lymph node metastatic tissue (LN)
To obtain the global landscape of Khib in ESCC metastasis, 20 cases of primary ESCC tumor tissue (T), matched normal tissue (N) and lymph node metastatic tissue (LN) were subjected to quantitative Khib proteomic analyses.
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD038252 | Pride
Proteomics Lysine 2-hydroxyisobutyrylation Cancer metastasis 
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