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ProteomicsProteomics of Temozolomide for Glioblastoma
Using the human glioblastoma cell line LN229, temozolomide was used to detect proteome changes and identify critical components regulating chemotherapy sensitivity.
ORGANISM(S): Homo sapiens (Human) 
2023-05-17 | PXD042080 | Pride
Human Glioblastoma Proteomics Temozolomide 
TranscriptomicsU-87 MG Temozolomide-Induced Senescence RNA-seq Dataset
We analyzed the U-87 MG cell line, which was treated with temozolomide for 5 days to induce a senescent state. The study aimed to investigate molecular and phenotypic alterations associated with senescence in the context of a malignant phenotype. Senescence was confirmed through β-galactosidase stai...
ORGANISM(S): Homo sapiens 
2025-05-14 | E-MTAB-15106 | biostudies-arrayexpress
TranscriptomicsPatients With Proneural Glioblastoma May Derive Overall Survival Benefit From the Addition of Bevacizumab to First-Line Radiotherapy and Temozolomide: Retrospective Analysis of the AVAglio Trial
The AVAglio and RTOG-0825 randomized, placebo-controlled phase III trials in newly diagnosed glioblastoma reported prolonged progression-free survival (PFS), but not overall survival (OS), with the addition of bevacizumab to radiotherapy/temozolomide. To establish whether certain patient subgroups d...
ORGANISM(S): Homo sapiens 
2016-07-06 | E-GEOD-84010 | biostudies-arrayexpress
TranscriptomicsGene profile of glioblastoma cells treated with y15 and temozolomide
The gene expression profiles were identified in glioblastoma cells treated with FAK inhibitor Y15, temozolomide alone or with combination of Y15 and Temozolomide DBTRG and U87 were treated with FAK inhibitor Y15 at 10 microM for 24 h; U87 cells were treated with Temozolomide 100 microM for 24 h and ...
ORGANISM(S): Homo sapiens 
2013-01-12 | E-GEOD-43452 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human-melanoma derived cell lines response to chemotherapy
To identify patterns of gene expression that correlate with response to treatment with either melphalan or temozolomide we measured both gene expression using microarray genechips and response to drug using a standard in vitro cell proliferation assay. Senstivity to melphalan was measured 48hrs aft...
ORGANISM(S): Homo sapiens 
2009-02-09 | E-GEOD-10916 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of primary human myeloid precursor cells treated with O6-benzylguanine (6BG) and Temozolomide (TMZ)
For the comparison of 6BG/TMZ with control sample, the predominant annotation among the upregulated genes is M-bM-^@M-^XapoptosisM-bM-^@M-^Y. The majority of the downregulated genes is assigned to heat shock proteins and proteins which bind unfolded proteins. To look at early changes in gene express...
ORGANISM(S): Homo sapiens 
2013-06-03 | E-GEOD-44122 | biostudies-arrayexpress
ProteomicsTemozolomide Induces Glioblastoma Dedifferentiation into Highly Malignant Stem-like Cells Through Senescence-Associated Reprogramming via HIF1α/HIF2α Regulation
A critical issue is that recurrent glioblastoma multiforme (GBM) after temozolomide (TMZ) exposure becomes more malignant, exhibiting higher invasion and stemness than the primary tumor. However, the detailed mechanism remains to be elucidated. While the majority of GBM cells succumb to TMZ treatmen...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058156 | Pride
Temozolomide Glioblastoma 
GenomicsMicroarray analysis of glioma cell lines : Temozolomide Sensitive vs. Resistant
Microarray analysis of glioma cell lines : Temozolomide Sensitive vs. Resistant
PRJNA798609 | ENA
GenomicsFBXO5 degrades DOK6 to enhance cell mechanics and sensitivity to Temozolomide
FBXO5 degrades DOK6 to enhance cell mechanics and sensitivity to Temozolomide
PRJNA1110241 | ENA
ModelsStephanou2019 - pH as a potential therapeutic target to improve temozolomide antitumor efficacy
Abstract: Despite intensive treatments including temozolomide (TMZ) administration, glioblastoma patient prognosis remains dismal and innovative therapeutic strategies are urgently needed. A systems pharmacology approach was undertaken to investigate TMZ pharmacokinetics‐pharmacodynamics (PK‐PD) inc...
2019-09-30 | MODEL1909300003 | BioModels
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