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ProteomicsHNF4α contributes to hepatic CAR dysfunction in polymicrobial sepsis
Constitutive androstane receptor (CAR) is a xenobiotic nuclear receptor mainly expressed in the liver, where it regulates drug metabolism and energy homeostasis. CAR has emerged as a promising therapeutic target for diabetes, fatty liver disease, and alcoholic liver disease, but it has not been inve...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-15 | PXD062961 | Pride
Lc-msms Clp-induced peritoneal sepsis Mouse Liver 
ProteomicsA new life-saving role for Glucocorticoid Receptor dimers: repressing STAT1-induced IFN response in the gut
The use of glucocorticoids (GCs), which bind and activate the glucocorticoid receptor (GR), in systemic inflammatory response syndromes (SIRS) is disputed. Mice with a poor transcriptional response of dimer-dependent GR target genes were studied in a model of TNF-induced SIRS. These GR dim/dim mice ...
ORGANISM(S): Mus musculus (Mouse) 
2019-04-01 | PXD008608 | Pride
Isg Inflammatory response Murine ileum Sirs Shotgun proteomics 
UnknownCDK4 phosphorylation status and rational use for combining CDK4/6 and BRAF/MEK inhibition in advanced thyroid carcinomas.
Not available
S-EPMC10641312 | biostudies-literature
MetabolomicsHepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis

Despite intensive research and constant medical progress, sepsis remains one of the most urgent unmet medical needs of today. Most studies have been focused on the inflammatory component of the disease, however, recent advances support the notion that sepsis is accompanied by extensive metabolic ...

2020-01-10 | MTBLS1386 | MetaboLights
TranscriptomicsGenome-wide analysis of LPS or PBS challenged DUSP3-KO and WT female mice peritoneal macrophages gene expression
Analysis of gene expression profile in peritoneal macrophage extracted from LPS or PBS challenged DUSP3-/- and WT mice. DUSP3 deletion protects mice from sepsis and endotoxemia. We performed a microarray analysis to get insights into the differentially regulated pathways between WT and KO under inf...
ORGANISM(S): Mus musculus 
2015-03-11 | E-GEOD-66782 | biostudies-arrayexpress
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