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ProteomicsLigand binding and conformational dynamics of the E. coli nicotinamide nucleotide transhydrogenase revealed by hydrogen/deuterium exchange mass spectrometry
Nicotinamide nucleotide transhydrogenases are integral membrane proteins that utilizes the proton motive force to reduce NADP+ to NADPH while converting NADH to NAD+. Atomic structures of various transhydrogenases in different ligand-bound states have become available, and it is clear that the molec...
ORGANISM(S): Escherichia coli 
2022-10-26 | PXD037413 | Pride
Channel opening Membrane protein Small ligand binding Hdx-ms Cyclic ims‑ms 
ProteomicsThe multivalency of the glucocorticoid receptor ligand-binding domain explains its manifold physiological activities
The glucocorticoid receptor (GR) is a ubiquitously expressed transcription factor that controls metabolic and homeostatic processes essential for life. Although numerous crystal structures of the GR ligand-binding domain (GR-LBD) have been reported, the functional oligomeric state of the full-length...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD028039 | Pride
Glucocorticoid receptor Mass spectrometry Ligand-binding domain Sectors X-ray crystallography Fluorescence microscopy Mutations Quaternary structure Glucocorticoids Homodimerization 
ProteomicsStructure of the Homodimeric Androgen Receptor Ligand-Binding Domain
The androgen receptor (AR) plays a crucial role in normal physiology, development and metabolism as well as in the etiology and treatment of diverse pathologies such as androgen insensitivity syndromes (AIS), male infertility, and prostate cancer (PCa). Here, we show that dimerization of AR ligand-b...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD005575 | Pride
Ar Cross-linking 
GenomicsThe multivalency of the glucocorticoid receptor ligand-binding domain explains its manifold physiological activities
The multivalency of the glucocorticoid receptor ligand-binding domain explains its manifold physiological activities
PRJNA878538 | ENA
GenomicsLigand-dependent dynamics of retinoic acid receptor binding during early neurogenesis
Among its many roles in development, retinoic acid determines the anterior-posterior identity of differentiating motor neurons by activating Retinoic Acid Receptor (RAR)-mediated transcription. RAR is thought to bind the genome constitutively, and only induce transcription in the presence of the ret...
ORGANISM(S): Mus musculus 
2010-12-10 | E-GEOD-19409 | biostudies-arrayexpress
GenomicsHomo sapiens
Effects of RARa ligand binding domain mutations on breast fibroepithelial tumor function and signaling
PRJNA868864 | ENA
UnknownEvidence for DNA-binding domain--ligand-binding domain communications in the androgen receptor.
Not available
S-EPMC3434514 | biostudies-literature
UnknownReversible domain closure modulates GlnBP ligand binding affinity.
Not available
S-EPMC9022810 | biostudies-literature
TranscriptomicsGlyco-gene expression in DP thymic T cells from control and mutant mice that carry a mutation in the ligand binding domain of Notch1
Dr. Stanley's laboratory is interested in determining how O-fucose glycans function in Notch receptor signaling and in modulating the interactions of Notch receptors with their ligands. We have generated mice carrying a point mutation in the ligand binding domain of Notch1 that reduces Notch ligand ...
ORGANISM(S): Mus musculus 
2011-04-29 | E-GEOD-28936 | biostudies-arrayexpress
UnknownLigand displaces heat shock protein 90 from overlapping binding sites within the aryl hydrocarbon receptor ligand-binding domain.
Not available
S-EPMC3186366 | biostudies-literature
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