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ProteomicsDomain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities
Mis-sense mutations affecting TP53 promote carcinogenesis both by inactivating its tumor suppressive functions, and by conferring aberrant pro-carcinogenic activities. We report here that mis-sense mutants in the p53 DNA-binding domain (DBD) and the transactivation domain (TAD) unexpectedly activate...
ORGANISM(S): Homo Sapiens (human) 
2023-02-17 | PXD031725 | JPOST Repository
TranscriptomicsscRNA-seq characterisation of in vitro-generated CD8+ exhausted human T cells
scRNA-seq was performed to characterise an in vitro model of T cell exhaustion. CD8+ T cells from two donors underwent chronic stimulation to induce exhaustion and samples were collected from multiple points across the protocol to examine the subsets and transcriptional signatures present.
ORGANISM(S): Homo sapiens 
2026-05-31 | E-MTAB-15435 | biostudies-arrayexpress
UnknownAURKB and PI3K/AKT/mTOR pathways converge to regulate <i>TERT</i> expression.
Not available
S-EPMC12356326 | biostudies-literature
UnknownEngineering self-propelled tumor-infiltrating CAR T cells using synthetic velocity receptors.
Not available
S-EPMC10760159 | biostudies-literature
TranscriptomicsChemical allergen-induced perturbations of the mouse lymph node DNA methylome
Epigenetic regulation of gene expression plays a pivotal role in the orchestration of immune responses and may determine the vigor, quality, or longevity of such responses. Chemical allergens can be divided into two categories: skin sensitizing chemicals associated with allergic contact dermatitis, ...
ORGANISM(S): Mus musculus 
2014-02-07 | E-GEOD-54768 | biostudies-arrayexpress
TranscriptomicsmiR-122 as a Regulator of Mitochondrial Metabolic Gene Network in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide, reflecting the need for a better understanding of hepatocarcinogenesis. In this study, we examined the genome-wide expression profiles of both miRNAs and mRNAs from paired tumor and adjacent non-tumor tissues fro...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-22058 | biostudies-arrayexpress
TranscriptomicsDNA methylation analysis of phaeochromocytoma, paraganglioma and normal adrenal medulla samples
Illumina Infinium MethylationEPIC BeadChip array files from phaeochromocytoma, paraganglioma tumours of different genotypes and normal adrenal medulla control samples. This is the first study using high-resolution MethylationEPIC arrays and also includes a large number of Cluster 1 tumours (n=16) wh...
ORGANISM(S): Homo sapiens 
2023-12-21 | E-MTAB-13433 | biostudies-arrayexpress
TranscriptomicsMelanomas enhance metastasis and resist BRAF-therapy through regulation of the scaffold protein FHL2 after loss of differentiation markers
To test whether or not the stable restoration of PMEL and FHL2 knockdown affects the oncogenic ability of into amelanotic melanoma cells. Global gene expression analysis performed to identify what different mechanisms and/or factors might be involved in cell motility and cell aggressiveness. A375M2 ...
ORGANISM(S): Homo sapiens 
2015-04-11 | E-GEOD-57348 | biostudies-arrayexpress
UnknownA Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles.
Not available
S-EPMC5833978 | biostudies-literature
TranscriptomicsSingle-cell transcriptional profiling of induced reprogramming trajectories
To elucidate the interplay between signal transduction and transcriptional regulation in cellular reprogramming, distinct induction routes from epiblast stem cells to naïve pluripotency were evaluated and compared.
ORGANISM(S): Mus musculus 
2019-08-16 | E-MTAB-7901 | biostudies-arrayexpress
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