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ProteomicsDimethyl Sulfoxide Enhances HLA Peptide Identification
Immunopeptidomics relies on LC-MS/MS for comprehensive profiling of HLA-bound peptides, yet detection remains challenging due to their non-tryptic nature, variable lengths, and lack of basic residues, which limit ionisation and fragmentation efficiency. To address these limitations, we investigated ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-30 | PXD072997 | Pride
Immunopeptidomics Dmso Supercharging 
ProteomicsIdentification of biological pathways and processes regulated by NEK5 in breast epithelial cells via an integrated proteomic approach
Specific members of the Nima-Related Kinase (NEK) family have been linked to cancer development and progression, and a role for NEK5, one of the least studied members, in breast cancer has recently been proposed. However, while NEK5 is known to regulate centrosome separation and mitotic spindle asse...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035322 | Pride
Neks  nek5  kinase  breast cancer  proteomics  bioid 
ProteomicsHuman Prostate Cancer epithelial-fibroblast cell signalling by CTAP-MS
A greater understanding of cell signaling events that occur within the prostate cancer tumor microenvironment (TME), for example between cancer-associated fibroblasts (CAFs) and prostate epithelial or cancer cells, may identify novel biomarkers and more effective therapeutic strategies for this dise...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037272 | Pride
Ctap-ms Human Caf Prostate Fibroblast 
ProteomicsImmunopeptidome of an acute myeloid leukemia cell line THP1
We report the use of complementary peptide antigen enrichment and comprehensive mass spectrometric acquisition strategies to provide in-depth immunopeptidome data for AML cell line THP1
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-07-09 | MSV000087786 | MassIVE
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