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ProteomicsIdentification of novel LIMK2 phosphorylation substrates
Breast cancer is the most common and a lethal form of cancer diagnosed in women worldwide. Although, effective treatment options for primary tumors are available, the majority of breast cancer-related deaths is caused by invasion of cells from primary tumor results in metastatic progression. Here we...
ORGANISM(S): Homo sapiens (Human) 
2020-08-31 | PXD008246 | Pride
Breast cancer Limk2 Phosphorylation Invasion 
GenomicsLIMK2 promotes melanoma tumor growth and metastasis through G3BP1-ESM1 pathway-mediated apoptosis inhibition
LIMK2 promotes melanoma tumor growth and metastasis through G3BP1-ESM1 pathway-mediated apoptosis inhibition
PRJNA787262 | ENA
TranscriptomicsLIMK2 promotes melanoma tumor growth and metastasis through G3BP1-ESM1 pathway-mediated apoptosis inhibition
Melanoma is the leading cause of skin cancer-related deaths, and current melanoma therapies, including targeted therapies and immunotherapies, benefit only a subset of metastatic melanoma patients due to either intrinsic or acquired resistance. LIM domain kinase 2 (LIMK2) is a serine/threonine kinas...
ORGANISM(S): Homo sapiens 
2023-03-16 | GSE190479 | GEO
UnknownKeratinocyte migration in the developing eyelid requires LIMK2.
Not available
S-EPMC3465268 | biostudies-literature
UnknownLIMK2-NKX3.1 Engagement Promotes Castration-Resistant Prostate Cancer.
Not available
S-EPMC8151535 | biostudies-literature
UnknownIdentification of LIMK2 as a therapeutic target in castration resistant prostate cancer.
Not available
S-EPMC7079209 | biostudies-literature
ProteomicsDiscovery and development of a potent LIMK2 isoform-specific degrader
The LIM kinases (LIMK1/2) are key mediators in the multi-step signaling cascades that regulate actin cytoskeleton dynamics via cofilin phosphorylation. Dysregulation of these pathways and overexpression of LIMKs are implicated in disease development, including cancer, Fragile X syndrome, and glaucom...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD067224 | Pride
Limk Protac 
ProteomicsDiscovery and development of a potent LIMK2 isoform-specific degrader
The LIM kinases (LIMK1/2) are key mediators in the multi-step signaling cascades that regulate actin cytoskeleton dynamics via cofilin phosphorylation. Dysregulation of these pathways and overexpression of LIMKs are implicated in disease development, including cancer, Fragile X syndrome, and glaucom...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD067130 | Pride
Limk Protac 
ProteomicsDiscovery and development of a potent LIMK2 isoform-specific degrader
The LIM kinases (LIMK1/2) are key mediators in the multi-step signaling cascades that regulate actin cytoskeleton dynamics via cofilin phosphorylation. Dysregulation of these pathways and overexpression of LIMKs are implicated in disease development, including cancer, Fragile X syndrome, and glaucom...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD067272 | Pride
Limk Protac 
UnknownLIMK2 promotes the metastatic progression of triple-negative breast cancer by activating SRPK1.
Not available
S-EPMC7455732 | biostudies-literature
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