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GenomicsTriplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation [ChIP-seq]
Children with Down syndrome (DS) have a 20-fold increased risk of developing B cell acute lymphoblastic leukemia (B-ALL). Polysomy 21 (i.e., extra copies of chr.21) is also the most frequent somatic aneuploidy among all B-ALLs. Additional B-ALLs harbor intrachromosomal amplifications of chr.21q22 (i...
ORGANISM(S): Mus musculus 
2014-04-20 | E-GEOD-48534 | biostudies-arrayexpress
UnknownOut-Of-Network Primary Care Is Associated With Higher Per Beneficiary Spending In Medicare ACOs.
Not available
S-EPMC7213776 | biostudies-literature
ProteomicsAutophagy cargo receptors are secreted via extracellular vesicles and particles in response to endolysosomal inhibition or impaired autophagosome maturation
The endosome-lysosome (endolysosome) system plays central roles in both autophagic degradation and secretory pathways, including the exocytic release of extracellular vesicles and particles (EVPs). Although previous work has revealed important interconnections between autophagy and EVP-mediated secr...
ORGANISM(S): Homo sapiens (Human) 
2022-03-03 | PXD031527 | Pride
Hek293t Tmt Extracellular vesicles Lc-ms/ms 
UnknownSurvival-inferred fragility of statistical significance in phase III oncology trials.
Not available
S-EPMC12289950 | biostudies-literature
UnknownSARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans.
Not available
S-EPMC8695127 | biostudies-literature
TranscriptomicsHuman lupus netting neutrophils induce endothelial damage, infiltrate tissues and expose immunostimulatory molecules
Our group has proposed that low-density granulocytes (LDGs) play an important role in lupus pathogenesis, as they can damage endothelial cells and synthesize increased levels of proinflammatory cytokines and type I interferons. LDGs have a heightened capacity to synthesize neutrophil extracellular t...
ORGANISM(S): Homo sapiens 
2011-06-22 | E-GEOD-26975 | biostudies-arrayexpress
GenomicsMassive Genomic Rearrangment Acquired in a Single Catastrophic Event During Cancer Development
Cancer is driven by mutation. Using Agilent exome hybridisation capture and Illumina GA massively parallel sequencing technology, we aim to sequence ~1600 microRNAs plus the protein coding genome of 25 matched human renal cancer samples. Bespoke algorithms are being developed to identify the somatic...
EGAS00000000029 | EGA
OtherAssessment of a method to characterize antibody selectivity and specificity for use in immunoprecipitation.
Data from ProteomeXchange, PXD ID: PXD002534. File: GR_130129_20_OT3_NT_L3MBTL2_FAB_31_G11_2_HEK293.mzXML. Published as part of Nat Methods. 2015 Jun 29 . From the Abstract: {{i}} ... We describe a mass spectrometry-based standard operating procedure for scoring immunoprecipitation antibody quality...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM32320016573 | GPMDB
Resource Reanalysis 
GenomicsMassive genomic rearrangement acquired in a single catastrophic event during cancer development - samples
Massive genomic rearrangement acquired in a single catastrophic event during cancer development
EGAD00001000002 | EGA
GenomicsEGAD00000000053
Sequencing data from Breast Cancer samples
EGAD00000000053 | EGA
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