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ProteomicsRb and the APC/C coactivator FZR1 determine CDK4/6-Cyclin D requirement in C. elegans and human cancer cells
Cyclin dependent kinase 4 and 6 (CDK4/6) in complex with D-type cyclins promote cell cycle entry, at least in part through phosphorylation of the retinoblastoma tumor suppressor protein (Rb). The CDK4/6-cyclin D-Rb pathway is commonly deregulated in human cancer, often through CDK4/6 or D-type cycli...
ORGANISM(S): Homo sapiens (Human) Caenorhabditis elegans 
2016-07-05 | PXD001501 | Pride
Lin-35 fzr1 
TranscriptomicsGene expression profiling of novel antigen presenting cells (APC) inducing pathogenic T helper cells of lupus
In lupus autoimmunity, pathogenic IgG autoantibodies that fix complement and bind FcGammaR on inflammatory cells, are produced with help from T helper (Th1 and Th17) cells specific for peptides from nucleosomes of apoptotic cells; and these Th cells also infiltrate vital organs (1-9). Macrophages (...
ORGANISM(S): Mus musculus 
2012-06-20 | E-GEOD-36284 | biostudies-arrayexpress
Unknown(O,O'-Diethyl dithio-phosphato-κS,S')(hydridotripyrazol-1-ylborato-κN,N,N)(triphenyl-phosphine-κP)ruthenium(II).
Not available
S-EPMC2959604 | biostudies-literature
TranscriptomicsHepatic transcriptome of mice fed high fat diets containing palm or linseed oil
The beneficial effects of dietary long-chain (LC) n-3 polyunsaturated fatty acids (PUFA) in the prevention and/or treatment of some metabolic disorders result largely from their capacity to regulate the transcription level of many genes involved in metabolic and physiological homeostasis, especially...
ORGANISM(S): Mus musculus 
2016-05-18 | E-GEOD-73290 | biostudies-arrayexpress
Unknown(Dithio-benzoato-κS,S')[hydridotris(pyrazol-1-yl-κN)borato](triphenyl-phosphine-κP)ruthenium(II).
Not available
S-EPMC2960112 | biostudies-literature
UnknownMethyl-ene bis-(dithio-benzoate).
Not available
S-EPMC2960133 | biostudies-literature
UnknownIncidence and Outcomes of Patients With Oral Cavity Squamous Cell Carcinoma and Fourth Primary Tumors: A Long-term Follow-up Study in a Betel Quid Chewing Endemic Area.
Not available
S-EPMC4998365 | biostudies-literature
UnknownRb and FZR1/Cdh1 determine CDK4/6-cyclin D requirement in C. elegans and human cancer cells.
Not available
S-EPMC4354291 | biostudies-literature
UnknownMethyl (2'S,3'S)-3,4-O-(2',3'-dimethoxy-butane-2',3'-di-yl)-α-l-rhamnopyran-oside: a glycosyl acceptor.
Not available
S-EPMC2961327 | biostudies-literature
MetabolomicsMitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis
Somatic DNMT3A R882 codon mutations drive the most common form of clonal haematopoiesis (CH) and are associated with increased acute myeloid leukaemia (AML) risk1,2. Preventing expansion of DNMT3A-R882-mutant haematopoietic stem/progenitor cells (HSPCs) may therefore avert progression to AML. To ide...
2025-02-06 | MTBLS12201 | MetaboLights
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