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ProteomicsLayers of regulation on cell-cycle gene expression in the budding yeast Saccharomyces cerevisiae
In the budding yeast Saccharomyces cerevisiae, transcription factors (TFs) regulate the periodic expression of many genes during the cell cycle, including gene products required for progression through cell-cycle events. Experimental evidence coupled with quantitative models suggest that a network o...
ORGANISM(S): Saccharomyces Cerevisiae 
PXD010937 | panorama
ProteomicsA chemoproteomics approach to profile phospholipase D-derived phosphatidyl alcohol interactions
Alcohol consumption leads to formation of phosphatidylethanol (PEth) via the transphosphatidylation activity of phospholipase D (PLD) enzymes. Though this non-natural phospholipid routinely serves as a biomarker of chronic alcoholism, its pathophysiological roles remain unknown. We use a minimalist ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-04 | PXD029749 | Pride
Cuaac Basigin Phosphatidyl ethanol Phosphatidic acid Diazirene Photoaffinity label Click chemistry Phospholipase d Phosphatidyl alcohol 
UnknownTranslational Breast Cancer Research Consortium (TBCRC) 022: A Phase II Trial of Neratinib for Patients With Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer and Brain Metastases.
Not available
S-EPMC5070554 | biostudies-literature
Proteomics4-deoxy-4-fluoro-GalNAz (4FGalNAz) is a metabolic chemical reporter of O-GlcNAc modifications, highlighting the notable substrate flexibility of O-GlcNAc transferase
Bioorthogonal chemistries have revolutionized many fields. For example, metabolic chemical reporters (MCRs) of glycosylation are analogs of monosaccharides that contain bioorthogonal functionality, like azides or alkynes. MCRs are metabolically incorporated into glycoproteins by living systems, and ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027333 | Pride
O-glcnac  tmt 
TranscriptomicsscRNAseq of olfactory mucosa and olfactory bulb of WT and Tspo knockout rats
We utilized single-cell RNA sequencing to examine gene expression changes in olfactory mucosa and olfactory bulb cells following knockout of translocator protein (18 kDa; Tspo) in Sprague Dawley rats. Tspo has been found to be highly expressed in the olfactory system in normal physiological conditio...
ORGANISM(S): Rattus norvegicus 
2026-10-09 | E-MTAB-15825 | biostudies-arrayexpress
TranscriptomicsWhole transcriptome sequencing of splenic influenza-specific CD8+ T cells in wt and Notch1/2ko mice
To more specifically determine whether the TEC program is controlled by Notch, we generated molecular definitions of TECs and MPCs by whole transcriptome sequencing of sorted KLRG1-CD127+ and KLRG1+CD127- H-2 Db-NP specific CD8+ T cell populations from wild-type mice. These definitions were used to ...
ORGANISM(S): Mus musculus 
2014-10-26 | E-MTAB-2999 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic stem cells and primordial germ cells to identify genes up-regulated in pluripotent cells
Understanding the transcriptional regulation of pluripotent cells is of fundamental interest and will greatly inform efforts aimed at directing differentiation of embryonic stem (ES) cells or reprogramming somatic cells. We first analyzed the transcriptional profiles of mouse ES cells and primordial...
ORGANISM(S): Mus musculus 
2007-07-28 | E-MEXP-1158 | biostudies-arrayexpress
TranscriptomicsKeratinocyte Growth Factor and Dexamethasone Plus Elevated cAMP Levels Synergistically Support Pluripotent Stem Cell Differentiation into Alveolar Epithelial Type II Cells.
Alveolar epithelial type II (ATII)-like cells can be generated from murine embryonic stem cells (ESCs), although to date, no robust protocols applying specific differentiation factors are established. We hypothesized that the keratinocyte growth factor (KGF), an important mediator of lung organogene...
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-33308 | biostudies-arrayexpress
MetabolomicsCell of origin epigenetic priming determines susceptibility to Tet2 mutation

Hematopoietic stem cell (HSC) mutations can result in clonal hematopoiesis (CH) with heterogeneous clinical outcomes. Here, we investigated how the cell state preceding Tet2 mutation impacts the pre-malignant phenotype. Using an inducible system for clonal analysis of myeloid progenitors...

2024-04-30 | MTBLS9914 | MetaboLights
TranscriptomicsmicroRNA expression profiling of lobular neoplasia
Invasive lobular carcinoma (ILC) of the breast accounts for 5-15% of breast cancers and is characterized by loss of E-cadherin and believed to arise via a linear histological progression. Genomic studies have identified a clonal relationship between ILC and concurrent lobular carcinoma in situ (LCIS...
ORGANISM(S): Homo sapiens 
2011-04-11 | E-GEOD-28514 | biostudies-arrayexpress
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