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ProteomicsNoncanonical amino acid-aided synthesis of anti-PD-L1 bispecific nanobody for colon cancer immunotherapy
Colorectal cancer (CRC) is the second leading cause of cancer-related mortality, and the incidence of early-onset colon cancer has been increasing globally in recent years. The development of immunotherapies for colon cancer is critical for providing new treatment strategies to combat drug resistanc...
ORGANISM(S): Escherichia coli 
2026-01-12 | PXD069482 | Pride
Bispecific antibody Maldi-tof Noncanonical amino acid 
MetabolomicsMethionine Intervention Induces PD-L1 Expression to Enhance the Immune Checkpoint Therapy Response in MTAP-deleted Osteosarcoma
Osteosarcoma (OS), a malignant bone tumor with limited treatment options, exhibits low sensitivity to immune checkpoint therapy (ICT). Through genomics and transcriptomics analyses, we have identified a subgroup of OS with methylthioadenosine phosphorylase (MTAP) deletion, which contributes to ICT r...
2026-06-09 | MTBLS11985 | MetaboLights
ProteomicsMachine learning-guided evolution of pyrrolysyl-tRNA synthetase for improved incorporation efficiency of diverse noncanonical amino acids
The pyrrolysyl-tRNA synthetase (PylRS) is widely used to incorporate noncanonical amino acids (ncAAs) into proteins. However, most of ncAA-containing protein yields remain low due to the limited activity of PylRS variants. Here, we apply machine learning (ML) to engineer the tRNA-binding domain of P...
ORGANISM(S): Escherichia coli 
2025-07-25 | PXD065336 | Pride
Lc-ms Sfgfp Noncanonical amino acids 
ProteomicsIntegrating Protein Language Models and Automatic Biofoundry for Enhanced Protein Evolution
Traditional protein engineering methods, such as directed evolution, while effective, are often slow and labor-intensive. Advances in machine learning and automated biofoundry present new opportunities for optimizing these processes. This study devises a protein language model-enabled automatic evol...
ORGANISM(S): Escherichia coli 
2024-12-25 | PXD058768 | Pride
Protein language models Protein engineering Directed evolution Automatic biofoundry 
ProteomicseIF3 subunit-specific mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content
eIF3, whose subunits are frequently overexpressed in cancer, regulates mRNA translation from initiation to termination, but mRNAeIF3, whose subunits are frequently overexpressed in cancer, regulates mRNA translation from initiation to termination, but mRNA-selective functions of individual subunits ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-14 | PXD034084 | Pride
Eif3 
ProteomicsThe proteomic raw data of livers of Takifugu obscurus under hypoxia or (and) infection of Vibrio parahaemolyticus
Takifugu obscurus was challenged by V. parahaemolyticus or (and) exposed to hypoxia. The effects of hypoxia and infection of V. parahaemolyticus were identified based on differential metabolites and proteins identified by methods of comparative metabolomics and proteomics on whole livers.
ORGANISM(S): Takifugu Obscurus 
PXD029027 |
UnknownRobust estimation of bacterial cell count from optical density.
Not available
S-EPMC7499192 | biostudies-literature
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