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MetabolomicsMitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis
Somatic DNMT3A R882 codon mutations drive the most common form of clonal haematopoiesis (CH) and are associated with increased acute myeloid leukaemia (AML) risk1,2. Preventing expansion of DNMT3A-R882-mutant haematopoietic stem/progenitor cells (HSPCs) may therefore avert progression to AML. To ide...
2025-02-06 | MTBLS12201 | MetaboLights
UnknownAccelerated methotrexate, vinblastine, doxorubicin, and cisplatin is safe, effective, and efficient neoadjuvant treatment for muscle-invasive bladder cancer: results of a multicenter phase II study with molecular correlates of response and toxicity.
Not available
S-EPMC4050203 | biostudies-literature
TranscriptomicsTranscriptional events during lung recovery from MRSA infection: a mouse pneumonia model
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is an emerging threat to human health throughout the world. Rodent MRSA pneumonia models mainly focus on the early innate immune responses to MRSA infection. However, the molecular pattern and mechanisms of recovery from MRSA...
ORGANISM(S): Mus musculus 
2013-11-12 | E-GEOD-36587 | biostudies-arrayexpress
TranscriptomicsUpregulated stromal EGFR and vascular remodeling in human NSCLC murine models (xenografts) of VEGF inhibitor resistance
The mechanisms by which tumors develop resistance to angiogenesis inhibitors, and the relative contributions of tumor cells and stroma to resistance, are not completely understood. We developed three human lung adenocarcinoma murine models of resistance to the VEGF inhibitor bevacizumab and, using s...
ORGANISM(S): Homo sapiens 
2011-04-22 | E-GEOD-26644 | biostudies-arrayexpress
UnknownImpact of age on outcomes after initial therapy with chemotherapy and different chemoimmunotherapy regimens in patients with chronic lymphocytic leukemia: results of sequential cancer and leukemia group B studies.
Not available
S-EPMC3731920 | biostudies-literature
UnknownPhase II Investigator-Initiated Study of Brentuximab Vedotin in Mycosis Fungoides and Sezary Syndrome With Variable CD30 Expression Level: A Multi-Institution Collaborative Project.
Not available
S-EPMC5089160 | biostudies-literature
UnknownThe research landscape and future of targeting super-enhancers for cancer therapy: a bibliometric analysis.
Not available
S-EPMC12923725 | biostudies-literature
ProteomicsIntegrin alpha1 beta1 promotes interstitial fibrosis and cyst growth in a mouse model of polycystic kidney disease
Background: Cystogenesis and interstitial fibrosis are contributing factors to kidney failure in individuals with autosomal dominant polycystic kidney disease (ADPKD). The molecular and cellular mechanisms involved in cyst growth and fibrosis are complex and new therapies are urgently needed to impr...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-07 | PXD072214 | Pride
Ecm Cyst Kidney Integrin 
UnknownOutcomes by tumor subtype and treatment pattern in women with small, node-negative breast cancer: a multi-institutional study.
Not available
S-EPMC4076026 | biostudies-literature
TranscriptomicsIdentification of a Potently Oncogenic CALM-AF10 Minimal-Fusion Mutant (miRNA)
The t(10;11) p (13;q14) translocation, giving rise to CALM-AF10, is a recurring chromosomal translocation observed in several types of acute leukemias as well as in lymphoma. We have previously demonstrated that the expression of the human CALM/AF10 fusion gene in murine bone marrow stem and progeni...
ORGANISM(S): Mus musculus 
2011-10-04 | E-GEOD-27512 | biostudies-arrayexpress
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