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The progression of replication forks is tightly regulated to ensure accurate genome duplication. We have found that these forks display biphasic dynamics throughout an unperturbed S phase, characterized by slow elongation in early S that transitions to rapid elongation in late S. In this study, we i...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD069962 | Pride
Staphylococcus aureus is an important human pathogen that causes life-threatening infections, and is resistant to the majority of our antibiotic arsenal. This resistance is complicated by the observation that most antibacterial agents target actively growing cells, thus, proving ineffective against ...
ORGANISM(S): Staphylococcus aureus 
Biopsies and surgical specimens were obtained from breast tumours treated and non-treated with celecoxib 400mg twice daily for 2 weeks
ORGANISM(S): Homo sapiens 

The Sjögren's International Collaborative Clinical Alliance (SICCA) is a multisite observational cohort study that recruited a large cohort of geographically diverse participants. Enrollment of participants began in late 2004 at five (one domestic and four international) sites, in which...

The reverse transsulfuration pathway is the major route for the metabolism of sulfur-containing amino acids. The role of this metabolic pathway in macrophage response and function is unknown. We show that the enzyme cystathionine γ-lyase (CTH) is induced in macrophages infected with pathogenic ba...

2020-05-15 | MTBLS696 | MetaboLights
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