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ProteomicsA new technology for isolating organellar membranes provides fingerprints of lipid bilayer stress
Biological membranes have a stunning ability to adapt their composition in response to physiological stress and metabolic challenges. Little is known how such perturbations affect individual organelles in eukaryotic cells. Pioneering work provided insights into the subcellular distribution of lipids...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-03-05 | PXD048553 | Pride
Organelle isolation Proteomics Upr Lipid bilayer stress Lipidomics Membrane 
ProteomicsTriglyceride induces ‌endoplasmic reticulum lipid bilayer stress to activate PERK and enhance antifungal immunity
Triglyceride synthesis promotes the activation of C-type lectin receptors signaling pathway upon fungal infection‌. Triglyceride synthesis induces endoplasmic reticulum lipid bilayer stress and activates the PERK kinase after fungal stimulation. PERK mediates autophagic degradation of SHP-1 to ampli...
ORGANISM(S): Mus Musculus 
2026-01-12 | PXD072975 |
GenomicsStress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress
Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress
PRJNA542716 | ENA
MetabolomicsMetabolomics-Based Analysis of Adaptive Mechanism of Eleutheronema tetradactylum to Low-Temperature Stress

Temperature is a critical environmental factor influencing fish physiology. Eleutheronema tetradactylum is an economically important warm-water species, but its response to long-term cold stress remains unclear. In this study, we exposed juvenile fish to 18 °C for 7 and 14 days and investigated h...

2026-09-08 | MTBLS15459 | MetaboLights
UnknownStress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress.
Not available
S-EPMC7337508 | biostudies-literature
TranscriptomicsStress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress
Membrane integrity at the endoplasmic reticulum (ER) is tightly regulated and its disturbance is implicated in metabolic diseases. Using an engineered sensor that activates the unfolded protein response (UPR) exclusively when normal ER membrane lipid composition is compromised, we identified pathway...
ORGANISM(S): Saccharomyces cerevisiae 
2020-04-24 | GSE131146 | GEO
MetabolomicsZinc oxide nanoparticles supplementation improve the quality and lipid profiles of boar frozen semen

Oxidative stress frequently causes a reduction in the quality of frozen-thawed sperm. Zinc oxide nanoparticles (ZnONPs) has an antioxidant protective effect on frozen semen of animals such as goats, camels and buffaloes. However, it is not clear whether ZnONPs can improve the quality and lipid co...

2026-05-05 | MTBLS12892 | MetaboLights
TranscriptomicsLipid bilayer stress-activated IRE-1 modulates autophagy during endoplasmic reticulum stress
Metabolic disorders such as obesity and nonalcoholic fatty liver disease (NAFLD) are emerging disorders that affect the global population. One facet of the disorders is attributed to the disturbance of membrane lipid homeostasis. Perturbation of endoplasmic reticulum (ER) homeostasis through changes...
ORGANISM(S): Caenorhabditis elegans 
2018-10-31 | GSE99763 | GEO
TranscriptomicsThe rsa1-1 mutation affects global gene expression in Arabidopsis thaliana with or without salt stress
Salt stress is one of the most severe environmental conditions which cause huge losses in crop production worldwide. We identified a novel calcium-binding protein and used the Affymetrix whole-genome arrays to define downstream targets of this important protein. We used the microarrays to reveal the...
ORGANISM(S): Arabidopsis thaliana 
2013-07-07 | E-GEOD-39236 | biostudies-arrayexpress
UnknownViscoelastic deformation of lipid bilayer vesicles.
Not available
S-EPMC4573909 | biostudies-literature
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