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ProteomicsMacrophage Proteomic Profiling Reveals Divergent TLR4-Dependent and -Independent Responses to Kdo₂-Lipid A and Lipid IVa
Immortalized mouse macrophages from wild type (WT) were treated with Kdo₂-Lipid A and Lipid IVa under three experimental conditions: (i) extracellular stimulation to assess TLR4-dependent activation with Kdo2 lipid A or lipid-IVa (Extra_Kdo2/Extra_IVa), (ii) direct cytosolic delivery by transfection...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-20 | PXD075293 | Pride
Kdo2-lipid a Lipid iva Tlr4-independent Macrophages Tlr4-dependent Proteomics 
TranscriptomicsTraDIS-Xpress finds mechanisms of action and synergies of a novel lipid IVA biosynthesis inhibitor
We used TraDIS-Xpress to determine the mechanism of action of a novel antimicrobial compound. We found that it inhibits lipid IVA biosynthesis in both Escherichia coli and Salmonella enterica serovar Typhimurium. We also were able to determine mechanisms of synergy with colistin, through ATP biosynt...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2023-08-31 | E-MTAB-13250 | biostudies-arrayexpress
GenomicsTraDIS-Xpress finds mechanisms of action and synergies of a novel lipid IVA biosynthesis inhibitor
TraDIS-Xpress finds mechanisms of action and synergies of a novel lipid IVA biosynthesis inhibitor
PRJEB65052 | ENA
ProteomicsMorquio A syndrome: identification of differential patterns of molecular pathway interactions in bone lesions
Mucopolysaccharidosis type IVA (MPS IVA; Morquio A syndrome) is a rare autosomal recessive lysosomal storage disease (LSD) caused by deficiency of a hydrolase enzyme, N-acetylgalactosamine-6-sulfate sulfatase, and characterized clinically by mainly musculoskeletal manifestations. The mechanisms unde...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-24 | PXD042166 | Pride
Morquio a syndrome Rare disease Swath-ms Protein biomarker 
UnknownElucidation of the MD-2/TLR4 interface required for signaling by lipid IVa.
Not available
S-EPMC7617842 | biostudies-literature
UnknownReviewing and identifying amino acids of human, murine, canine and equine TLR4 / MD-2 receptor complexes conferring endotoxic innate immunity activation by LPS/lipid A, or antagonistic effects by Eritoran, in contrast to species-dependent modulation by lipid IVa.
Not available
S-EPMC3962135 | biostudies-literature
UnknownCrystal structure of soluble MD-1 and its interaction with lipid IVa.
Not available
S-EPMC2890730 | biostudies-literature
UnknownThree-dimensional mapping of differential amino acids of human, murine, canine and equine TLR4/MD-2 receptor complexes conferring endotoxic activation by lipid A, antagonism by Eritoran and species-dependent activities of Lipid IVA in the mammalian LPS sensor system.
Not available
S-EPMC3962092 | biostudies-literature
TranscriptomicsLipopolysaccharide (LPS) response in macrophages from MD-2-deficient mice
Lipid A (a hexaacylated 1,4 bis-phosphate) is a potent immune stimulant for TLR4/MD-2. Upon lipid A ligation, the TLR4/MD-2 complex dimerizes and initiates signal transduction. Historically, studies also suggested the existence of TLR4/MD-2-independent LPS signaling. Here we define the role of TLR4...
ORGANISM(S): Mus musculus 
2011-07-30 | E-GEOD-31067 | biostudies-arrayexpress
UnknownJNK and ceramide kinase govern the biogenesis of lipid droplets through activation of group IVA phospholipase A2.
Not available
S-EPMC2781651 | biostudies-literature
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