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MetabolomicsLC-MS/MS targeted analysis of ferroptosis-associated phospholipid peroxidation in KIF11-depleted HRECs

Human retinal vascular endothelial cells (HRECs) were transfected with lentivirus encoding either KIF11-targeting shRNA or a non-targeting control. KIF11-depleted and control cells were then subjected to lipid extraction followed by LC–MS/MS–based targeted analysis of ferroptosis-associated phosp...

2026-02-13 | MTBLS12912 | MetaboLights
ProteomicsChemotherapy-induced cellular senescence is characterized by aberrant lipid regulation and lipid peroxidation
As normal cells approach their proliferative limit, they arrest to undergo replicative senescence, displaying large cell size, flat morphology and activation of senescence-associated beta-galactosidase (SA-b-Gal). A subset of normal or tumor cells exposed in vitro or in vivo to chemotherapy agents s...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-06 | PXD006216 | Pride
Maxquant lfq Lipid peroxidation Mus Q-exactive Chemotherapy-induced senescence Quant proteomics 
MetabolomicsB cell expression of the enzyme PexRAP, an intermediary in ether lipid biosynthesis, promotes antibody responses and germinal center size.

The qualities of antibody (Ab) responses provided by B lymphocytes and their plasma cell (PC) descendants are crucial facets of responses to vaccines and microbes. Metabolic processes and products regulate aspects of B cell proliferation and differentiation into germinal center (GC) and PC states...

2026-04-13 | MTBLS13880 | MetaboLights
GenomicsTRAF3 loss protects glioblastoma cells from lipid peroxidation and immune elimination via dysregulated lipid metabolism
TRAF3 loss protects glioblastoma cells from lipid peroxidation and immune elimination via dysregulated lipid metabolism
PRJNA1206985 | ENA
ProteomicsReprogramming the Lipid Peroxidation Product 4-ONE as a Chemoselective Cleavable Crosslinker
Nature builds and stabilizes proteins through covalent biological glues, yet the logic and traceability of metabolite-driven crosslinking remain obscure. Here we reprogram the lipid peroxidation product 4-oxo-nonenal (4-ONE) into a metabolite-derived Cys-Lys biological glue and mass-cleavable crossl...
ORGANISM(S): Homo sapiens (Human) 
2026-06-22 | PXD077887 | Pride
4-one Peroxidation Mass spectrometry Crosslink Lipid 
ProteomicsReprogramming the Lipid Peroxidation Product 4-ONE as a Chemoselective Cleavable Crosslinker
Nature builds and stabilizes proteins through covalent biological glues, yet the logic and traceability of metabolite-driven crosslinking remain obscure. Here we reprogram the lipid peroxidation product 4-oxo-nonenal (4-ONE) into a metabolite-derived Cys-Lys biological glue and mass-cleavable crossl...
ORGANISM(S): Homo sapiens (Human) 
2026-06-22 | PXD077820 | Pride
4-one Peroxidation Mass spectrometry Crosslink Lipid 
GenomicsGTP Cyclohydrolase I Confers Metabolic Protection Against Lipid Peroxidation in Glioblastoma
GTP Cyclohydrolase I Confers Metabolic Protection Against Lipid Peroxidation in Glioblastoma
PRJNA1055602 | ENA
ProteomicsHDAC inhibitors activate lipid peroxidation and ferroptosis in gastric cancer
Purpose: Gastric cancer remains one of the deadliest neoplasms worldwide, with a high need for new therapeutic options. Efficacies of targeted therapies are often limited owing to the inter- and intratumoral heterogeneity of gastric cancer. Thus, drugs with broader mechanisms of action rather than r...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD050328 | Pride
Lipid peroxidation Proteomics Ferroptosis Hdaci 
GenomicsALOX15B controls macrophage cholesterol homeostasis via lipid peroxidation, ERK1/2 and SREBP2
ALOX15B controls macrophage cholesterol homeostasis via lipid peroxidation, ERK1/2 and SREBP2
PRJNA858538 | ENA
GenomicsCandida albicans pathways that protect against organic peroxides and lipid peroxidation.
Candida albicans pathways that protect against organic peroxides and lipid peroxidation.
PRJNA1151126 | ENA
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