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MetabolomicsRetromer mediates Ypt7-dependent lipid droplet internalization

Lipid droplets (LDs) are dynamic organelles central to cellular energy homeostasis and stress adaptation. Maintaining LD balance is critical for cell function, yet the mechanisms governing selective LD degradation remain unclear. Here, we reveal a pathway promoting efficient vacuolar sequestering...

2026-07-15 | MTBLS15038 | MetaboLights
GenomicsFlattened circadian glucocorticoid oscillations cause obesity due to increased lipid turnover and lipid uptake
Flattened circadian glucocorticoid oscillations cause obesity due to increased lipid turnover and lipid uptake
PRJNA837272 | ENA
ProteomicsRab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells
Rab GTPases recruit peripheral membrane proteins and can define organelle identity. Rab18 localizes to the ER but also to the surfaces of lipid droplets (LDs), where it has been implicated in effector protein recruitment and in defining LD identity. Here, we studied Rab18 localization and function i...
ORGANISM(S): Homo sapiens (Human) 
2018-06-06 | PXD009683 | Pride
Triacylglycerol Lipid droplet Endoplasmic reticulum Rab18 Neutral lipid storage Rabgtpase 
UnknownImaging regiospecific lipid turnover in mouse brain with desorption electrospray ionization mass spectrometry.
Not available
S-EPMC5580901 | biostudies-literature
UnknownSpartin-mediated lipid transfer facilitates lipid droplet turnover.
Not available
S-EPMC10705495 | biostudies-literature
UnknownSpartin-mediated lipid transfer facilitates lipid droplet turnover.
Not available
S-EPMC10801920 | biostudies-literature
ProteomicsProtein turnover rate along the gastrointestinal tract is coordinated by the spatial location and the microbiota
The gastrointestinal tract is covered by a single layer of epithelial cells that, together with the mucus layers, protect the underlying tissue from bacterial invasion. The epithelium has one of the highest turnover rates in the body, renewing every 4-5 days. Using stable isotope labelling, high-res...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-24 | PXD011457 | Pride
Germ-free Colon Mass spectrometry Protein turnover Commensals Lipid metabolism Proteomics Colonization Small intestine Bacteria 
ProteomicsAlkylation Damage by Lipid Electrophiles Targets Functional Protein Systems
These data correspond to "Alkylation Damage by Lipid Electrophiles Targets Functional Protein Systems," a paper from Codreanu, Liebler, et al, published at the journal _Molecular and Cellular Proteomics_ in 2013. Modifications also include: 4-hydroxynonenal (HNE) (UniMod #53), H(16) C(9) O(2), Mono...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2013-11-18 | MSV000078490 | MassIVE
MetabolomicsLipids in the escalated host-pathogen arms race

Lipids, fundamental constituents of cell membranes, cellular energy carriers, and signaling molecules, play a pivotal role in the interaction between pathogens and hosts. During microbial infections, lipids not only fuel the activation of the immune system but also, acting as signaling molec...

2025-07-05 | MTBLS12678 | MetaboLights
ProteomicsAlkylation Damage by Lipid Electrophiles-- HNE-induced expression in RKO cells
4-hydroxynonenal (HNE) (UniMod 53) (+156.115030 Da on Cys, His, Lys) reduced 4-Hydroxynonenal (UniMod 335(+158.130680 Da on Cys, His, Lys) These data were additions to the set for the paper Alkylation Damage by Lipid Electrophiles Targets Functional Protein Systems by Codreanu et al, Mol. Cell. Pro...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2013-12-18 | MSV000078512 | MassIVE
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