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ProteomicsRegulation of lipid metabolism gene expression in the C. elegans nervous system occurs via altering the repertoire of RNA binding proteins present on specific transcripts
Tissue-specific regulation of gene expression is essential for multicellular organisms, and RNA binding proteins play central roles in these molecular processes. To determine how the Caenorhabditis elegans RNA binding protein ADR-1 regulates tissue-specific gene expression, we profiled the binding t...
ORGANISM(S): Caenorhabditis Elegans (ncbitaxon:6239) 
2025-02-21 | MSV000097188 | MassIVE
MetabolomicsTargeting the SREBP-dependent lipidomic reprogramming by virus infection for broad-spectrum therapeutic intervention
Viruses are obligate intracellular parasites that exploit the host metabolic machineries to meet their extraordinary biosynthetic demands. Integrative transcriptomic and lipidomic profiling confirmed that Middle East respiratory syndrome coronavirus (MERS-CoV) infection reprograms the host lipid met...
2018-11-26 | MTBLS762 | MetaboLights
TranscriptomicsAdiponectin regulates expression of hepatic genes critical for glucose and lipid metabolism.
The effects of adiponectin on hepatic glucose and lipid metabolism at transcriptional level are largely unknown. We profiled hepatic gene expression in adiponectin knockout (KO) and wild-type (WT) mice by RNA-Seq. Comparing to WT mice, adiponectin KO mice exhibited decreased mRNA expression of rate-...
ORGANISM(S): Mus musculus 
2012-09-04 | E-GEOD-38144 | biostudies-arrayexpress
GenomicsGDPD5-CD55-EGFR Competitive Binding Axis Regulates Radioresistance and Lipid Accumulation in Rectal Cancer
GDPD5-CD55-EGFR Competitive Binding Axis Regulates Radioresistance and Lipid Accumulation in Rectal Cancer
PRJNA1422628 | ENA
ProteomicsStructural basis for lipid binding and function by an evolutionally conserved protein, Serum Amyloid A
Serum amyloid A (SAA) is a plasma protein that transports lipids during inflammation. To explore SAA solution conformations and lipid binding mechanism, we used hydrogen-deuterium exchange mass spectrometry, lipoprotein reconstitution, sequence analysis and molecular dynamics simulations. Solution ...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-17 | PXD016391 | Pride
Hydrogen-deuterium exchange mass spectrometry  molecular dynamics simulations  lipoprotein nanoparticle  intrinsically disordered protein  β-hairpin misfolding intermediate  inflammation and immunity 
GenomicsChemicals targeting Lipid binding domain (LBD) of 38γ
Chemicals targeting Lipid binding domain (LBD) of 38γ
PRJNA756369 | ENA
ProteomicsAqpZ Single Mutant and Double Mutant Cycle Native MS
Native MS analysis of single mutant and double mutant cycle experiments. See: https://www.biorxiv.org/content/10.1101/2023.09.19.558516v1
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2023-10-06 | MSV000093064 | MassIVE
GenomicsDNA G-quadruplex structure participates in regulation of lipid metabolism through Acyl-CoA binding protein
DNA G-quadruplex structure participates in regulation of lipid metabolism through Acyl-CoA binding protein
PRJNA833674 | ENA
ProteomicsDoa10/MARCH6 architecture interconnects E3 ligase activity with lipid-binding transmembrane channel to regulate SQLE
Transmembrane E3 ligases play crucial roles in homeostasis. Much protein and organelle quality control, and metabolic regulation, are determined by ER-resident MARCH6 E3 ligases, including Doa10 in yeast. Here, we present Doa10/MARCH6 structural analysis by cryo-EM and AlphaFold predictions, and a s...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD047499 | Pride
Ubiquitylation E3 ubiquitin ligases March6 Membrane proteins Doa10 Cryo-em Sqle 
GenomicsExamination of hepatic SREBP-2 binding using ChIP-Seq
Sterol regulatory element binding proteins (SREBPs) are key transcriptional regulators of lipid metabolism. To define functional differences between the three mammalian SREBPs we are using genome-wide ChIP-seq with isoform-specific antibodies and chromatin from select tissues of mice challenged with...
ORGANISM(S): Mus musculus 
2011-03-22 | E-GEOD-28082 | biostudies-arrayexpress
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