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MetabolomicsA synthetic cell with integrated DNA self-replication and lipid biosynthesis

The emergence, organization, and persistence of cellular life are the result of the functional integration of metabolic and genetic networks. Here, we engineer phospholipid vesicles that can operate three essential functions, namely transcription-translation of a partial genome, self-replication ...

2026-02-02 | MTBLS13437 | MetaboLights
ProteomicsIdentification of proteins interacting with the small GTPase Arl4D by liposome flotation assay and mass spectrometry
N-terminal myristoylation serves as an important modification for membrane insertion and concrete membrane anchoring of the small GTPases ADP-ribosylation factor (Arf) and ADP ribosylation factor-like (Arl). To simulate the binding topology of Arl4D on the membrane, we performed the liposome flotati...
ORGANISM(S): Homo sapiens (Human) 
2025-05-10 | PXD054952 | Pride
Erk2 Small gtpase arl4d Liposome flotation 
UnknownTLC599 in patients with osteoarthritis of the knee: a phase IIa, randomized, placebo-controlled, dose-finding study.
Not available
S-EPMC8862584 | biostudies-literature
GenomicsEffect of liposome on gene expression of splenic macrophages
Effect of liposome on gene expression of splenic macrophages
PRJNA521377 | ENA
ProteomicsEffect of liposome rigidity on corona formation and its implications for uptake by cells
Nanoparticle rigidity influences cellular uptake and in vivo behavior, yet the underlying mechanisms remain unclear. Here, we used lipids with identical head groups but different alkyl chains to prepare liposomes with comparable surface composition, size and zeta potential, but distinct mechanical p...
ORGANISM(S): Bos taurus (Bovine) 
2026-10-05 | PXD079018 | Pride
Nanoparticle corona Nanoparticle rigidity Atomic force microscopy Cellular uptake Liposome 
ProteomicsTuning Liposome Composition to Modulate the Corona Forming in Human Serum and Uptake by Cells
Nano-sized objects such as liposomes are modified by adsorption of biomolecules in biological fluids. The resulting corona critically changes nanoparticle behavior at cellular level. A better control of corona composition could allow to modulate uptake by cells. Within this context, in this work, li...
ORGANISM(S): Homo sapiens (Human) 
2020-02-28 | PXD017776 | Pride
Nanoparticle corona Human serum Liposomes Cellular uptake 
GenomicsRedox disruption using electroactive liposome coated gold nanoparticles for cancer therapy
Redox disruption using electroactive liposome coated gold nanoparticles for cancer therapy
PRJNA1201063 | ENA
ProteomicsTargeted proteomics measurements for Genetically controlled membrane synthesis in liposomes
Lipid membranes, nucleic acids, proteins, and metabolism are essential for modern cellular life. Synthetic systems emulating the fundamental properties of living cells must therefore be built upon these functional elements. In this work, phospholipid-producing enzymes encoded in a synthetic minigeno...
ORGANISM(S): Escherichia Coli 
2021-03-12 | PXD020399 | panorama
UnknownEffects of the protein corona on liposome-liposome and liposome-cell interactions.
Not available
S-EPMC4938145 | biostudies-literature
GenomicsMitoxantrone-liposome sensitizes Flt3-ITD acute myeloid leukemia to gilteritinib treatment
Mitoxantrone-liposome sensitizes Flt3-ITD acute myeloid leukemia to gilteritinib treatment
PRJNA1156893 | ENA
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