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TranscriptomicsIdentification of Dysregulated Long Noncoding RNAs in the Midbrain of Human Cocaine Abusers
Maintenance of the drug-addicted state involves changes in gene expression in different neuronal cell types and neural circuits. Midbrain dopamine neurons in particular mediate numerous responses to drugs of abuse. Long noncoding RNAs (lncRNAs) regulate CNS gene expression through a variety of mecha...
ORGANISM(S): Homo sapiens 
2015-07-04 | E-GEOD-67281 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array time series of human MCF7 breast cancer cells treated with estradiol
Using a chromatin immunoprecipitation-paired end diTag cloning and sequencing strategy, we mapped estrogen receptor alpha (ERalpha) binding sites in MCF-7 breast cancer cells. We identified 1,234 high confidence binding clusters of which 94% are projected to be bona fide ERalpha binding regions. Onl...
ORGANISM(S): Homo sapiens 
2009-01-09 | E-GEOD-11352 | biostudies-arrayexpress
TranscriptomicsDevelopmental Changes in the Transcriptome of Human Cerebral Cortex Tissue: Long Noncoding RNA Transcripts
To examine the hypothesis that lncRNA expression varies with age, potentially paralleling 25 known developmental trends in synaptogenesis, myelination, and energetics, we quantified levels of nearly 6000 lncRNAs in 36 surgically resected human neocortical samples (primarily derived from temporal cor...
ORGANISM(S): Homo sapiens 
2013-01-19 | E-GEOD-43639 | biostudies-arrayexpress
TranscriptomicsOntogenetic study of gene expression in human cerebral cortex tissue using genome-wide microarray
In this study we sought to examine gene expression in the cerebral cortex during development in the context of adaptive plasticity. In order to do this we introduced an approach designed to discriminate genes with variable as opposed to uniform patterns of gene expression and found that greater inte...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-37721 | biostudies-arrayexpress
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