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MetabolomicsABHD11/ROLIP maintains the TCA cycle by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
2-oxoglutarate (2-OG) relates mitochondrial metabolism to cell function: conversion of 2-OG to succinyl-CoA by the 2-OG dehydrogenase complex (OGDHc) is rate-limiting for the Tricarboxylic Acid (TCA) cycle, but 2-OG is also required for oxygen sensitive enzymes (2-OG dependent dioxygenases) that hav...
2020-08-10 | MTBLS1875 | MetaboLights
Unknownp32 regulates glycometabolism and TCA cycle to inhibit ccRCC progression via copper-induced DLAT lipoylation oligomerization.
Not available
S-EPMC10758103 | biostudies-literature
UnknownMethionine restriction constrains lipoylation and activates mitochondria for nitrogenic synthesis of amino acids.
Not available
S-EPMC10154411 | biostudies-literature
UnknownFDX1 regulates cellular protein lipoylation through direct binding to LIAS.
Not available
S-EPMC9915701 | biostudies-literature
UnknownFDX1 regulates cellular protein lipoylation through direct binding to LIAS.
Not available
S-EPMC10462841 | biostudies-literature
ProteomicsMitoSAM-dependent lipoylation controls postnatal heart development via metabolic remodeling
The neonatal heart undergoes a rapid metabolic transition from fetal glycolysis to oxidative phosphorylation, requiring coordinated remodeling of mitochondrial metabolism. The mechanisms driving this transition remain unclear. Here, we demonstrate that sufficient mitochondrial S-adenosylmethionine (...
ORGANISM(S): Mus Musculus (mouse) 
2026-06-22 | PXD070035 | JPOST Repository
ProteomicsMitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria
Cells harbor two systems for fatty acid synthesis, one in the cytoplasm (catalyzed by fatty acid synthase, FASN) and one in the mitochondria (mtFAS). In contrast to FASN, mtFAS is poorly characterized, especially in higher eukaryotes, with the major product(s), metabolic roles, and cellular function...
ORGANISM(S): Homo sapiens (Human) 
2020-09-02 | PXD021034 | Pride
Metabolism Mitochondria Electron transport chain Fatty acid synthesis Oxphos Respiration Reductive carboxylation Lipoylation tca cycle Muscle 
GenomicsDrosophila melanogaster
Metabolomic analysis of lipt2 mutant in drosophila
PRJDB42279 | ENA
UnknownImmune patterns of cuproptosis in ischemic heart failure: A transcriptome analysis.
Not available
S-EPMC10955177 | biostudies-literature
UnknownCuproptosis predicts the risk and clinical outcomes of lung adenocarcinoma.
Not available
S-EPMC9393616 | biostudies-literature
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