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TranscriptomicsMapping high resolution, multidimensional phase diagrams of physiological protein condensates
Total RNA-seq was performed on HeLa cells to investigate transcriptomic changes associated with physiological protein condensates. rRNA was depleted using NEBNext rRNA Depletion Kit. Strand-specific libraries were prepared using QIAseq FastSelect and NEBNext Ultra II Directional RNA Library Prep Kit...
ORGANISM(S): Homo sapiens 
2026-06-13 | E-MTAB-17121 | biostudies-arrayexpress
TranscriptomicsEngineering Material Properties of Transcription Factor Condensates to Control Gene Expression in HEK-293T Cells
Phase separation of biomolecules into condensates is a key mechanism in the spatiotemporal organization of biochemical processes in cells. We systematically engineered light-inducible transcription factor condensates with different material properties and analyzed their influence on transcription ac...
ORGANISM(S): Homo sapiens 
2024-04-01 | E-MTAB-13905 | biostudies-arrayexpress
GenomicsATRX Condensates Formed by Liquid-Liquid Phase Separation Regulate Neural Progenitor Cell Identity (ChIP)
ATRX Condensates Formed by Liquid-Liquid Phase Separation Regulate Neural Progenitor Cell Identity (ChIP)
PRJNA1159201 | ENA
GenomicsATRX Condensates Formed by Liquid-Liquid Phase Separation Regulate Neural Progenitor Cell Identity (RNA)
ATRX Condensates Formed by Liquid-Liquid Phase Separation Regulate Neural Progenitor Cell Identity (RNA)
PRJNA1159200 | ENA
GenomicsSpatiotemporal regulation of liquid-like condensates in epigenetic inheritance
Spatiotemporal regulation of liquid-like condensates in epigenetic inheritance
PRJNA439309 | ENA
UnknownSmall Molecules Modulate Liquid-to-Solid Transitions in Phase-Separated Tau Condensates.
Not available
S-EPMC9156559 | biostudies-literature
GenomicsATRX Condensates Formed by Liquid-Liquid Phase Separation Regulate Neural Progenitor Cell Identity (ChIP)
Alpha-thalassemia X-linked intellectual disability syndrome (ATR-X) is caused by mutations in the ATRX gene, which plays a pivotal role in heterochromatin integrity. In this study, we uncover a novel mechanism by which ATRX influences fate of human neural progenitor cells (hNPCs) through the formati...
ORGANISM(S): Homo sapiens 
2025-07-13 | GSE276835 | GEO
TranscriptomicsATRX Condensates Formed by Liquid-Liquid Phase Separation Regulate Neural Progenitor Cell Identity (RNA)
Alpha-thalassemia X-linked intellectual disability syndrome (ATR-X) is caused by mutations in the ATRX gene, which plays a pivotal role in heterochromatin integrity. In this study, we uncover a novel mechanism by which ATRX influences fate of human neural progenitor cells (hNPCs) through the formati...
ORGANISM(S): Homo sapiens 
2025-07-13 | GSE276834 | GEO
ProteomicsRabies virus P protein binds to TBK1 and interferes with the formation of innate immunity-related liquid condensates
Viruses must overcome the interferon-mediated antiviral response to replicate and propagate into their host. Rabies virus (RABV) phosphoprotein P is known to inhibit interferon induction. Here, using a global mass spectrometry approach, we show that RABV P binds to TBK1, a kinase located at the cros...
ORGANISM(S): Homo sapiens (Human) 
2025-09-11 | PXD063965 | Pride
Viral Tbk1 Virus Interferon Factories Liquid condensates Rabies 
ProteomicsPhosphorylation regulates viral biomolecular condensates to promote infectious progeny production
Biomolecular condensates play important roles in diverse biological processes. Many viruses form biomolecular condensates which have been implicated in various functions critical for productive infection of host cells. The adenovirus L1-52/55 kilodalton protein (52K) was recently shown to form viral...
ORGANISM(S): Homo sapiens (Human) 
2023-12-06 | PXD046971 | Pride
Biomolecular condensates Phosphorylation Virus 
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