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TranscriptomicsChemical modifications mark alternatively spliced and actively degrading messenger RNAs in Arabidopsis and humans
Post-transcriptional chemical modification of RNA bases is a widespread and physiologically relevant regulator of RNA maturation, stability, and function. While modifications are best characterized in short, noncoding RNAs such as transfer RNAs (tRNAs), growing evidence indicates that messenger RNAs...
ORGANISM(S): Homo sapiens 
2015-10-31 | E-GEOD-66224 | biostudies-arrayexpress
UnknownBalancing medicine prices and business sustainability: analyses of pharmacy costs, revenues and profit shed light on retail medicine mark-ups in rural Kyrgyzstan.
Not available
S-EPMC2914726 | biostudies-literature
MetabolomicsOptimised LC-MS Metabolomic Profiling Reveals Emergent Changes to Monocyte Metabolism in Response to Lipopolysaccharide
Immunometabolism examines the links between immune cell function and metabolism. Dysregulation of immune cell metabolism is now an established feature of innate immune cell activation. Advances in liquid chromatography mass spectrometry (LC-MS) technologies have allowed discovery of unique insights ...
2025-11-17 | MTBLS6730 | MetaboLights
UnknownBacterial community dynamics during embryonic development of the little skate (Leucoraja erinacea).
Not available
S-EPMC8513177 | biostudies-literature
MetabolomicsB cell expression of the enzyme PexRAP, an intermediary in ether lipid biosynthesis, promotes antibody responses and germinal center size.

The qualities of antibody (Ab) responses provided by B lymphocytes and their plasma cell (PC) descendants are crucial facets of responses to vaccines and microbes. Metabolic processes and products regulate aspects of B cell proliferation and differentiation into germinal center (GC) and PC states...

2026-04-13 | MTBLS13880 | MetaboLights
TranscriptomicsBlood transcriptomes of chronic HCV patients four years after therapy-induced viral clearance
Little is known on the immune status in liver and blood of chronic HCV patients long after therapy-induced viral clearance. In this study, we demonstrate that 4 years after clearance, regulation of HCV-specific immunity in blood by regulatory T-cells (Treg) and the immunosuppressive cytokines IL-10 ...
ORGANISM(S): Homo sapiens 
2015-04-06 | E-GEOD-64603 | biostudies-arrayexpress
UnknownUse of Photo-Identification and Mark-Recapture Methodology to Assess Basking Shark (Cetorhinus maximus) Populations.
Not available
S-EPMC4773138 | biostudies-literature
ProteomicsInhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
Expression of tryptophan 2,3-dioxygenase (TDO) is a determinant of malignancy in gliomas through kynurenine (KYN) signaling. We report that inhibition of TDO activity attenuated recovery from replication stress and increased the genotoxic effects of bis-chloroethylnitrosourea (BCNU). Activation of t...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022351 | Pride
Dna repair Dna damage Tryptophan 2 Kynurenine Replication stress 3-dioxygenase Dna replication 
TranscriptomicsLinkage of genomic biomarkers to whole organism endpoints in a Toxicity Identification Evaluation (TIE)
Aquatic organisms are exposed to many toxic chemicals and interpreting the cause and effect relationships between occurrence and impairment is difficult. Toxicity Identification Evaluation (TIE) provides a systematic approach for identifying responsible toxicants. TIE relies on relatively uninforma...
ORGANISM(S): Ampelisca abdita 
2012-12-21 | E-GEOD-41463 | biostudies-arrayexpress
TranscriptomicsDetecting novel genes with sparse arrays
Species-specific genes play an important role in defining the phenotype of an organism. However, current gene prediction methods can only efficiently find genes that share features such as sequence similarity or general sequence characteristics with previously known genes. Novel sequencing methods a...
ORGANISM(S): Hypocrea jecorina 
2010-08-12 | E-GEOD-12960 | biostudies-arrayexpress
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