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TranscriptomicsAmplification of RANK- and c-Met-mediated signaling promotes metastatic colonization
We found that RANKL, expressed by cancer cells or derived from exogenous sources, consistently induced human prostate, breast, kidney, lung and liver cancer cells to colonize or metastasize to bone in an animal model of cancer bone metastasis. RANK-mediated signaling established a premetastatic nich...
ORGANISM(S): Homo sapiens 
2014-02-06 | E-GEOD-48432 | biostudies-arrayexpress
TranscriptomicsAltered genes expression profile of Rep2 mutants in Fission Yeast upon HU treatment.
Expression profiles indicate that C-terminal of rep2 is essential for its transactivation activity. Keywords: rep2 mutants cells treated with 8 mM HU for different time points vs wildtype untreated cells We analyzed 40 arrays for rep2 mutants cells treated with 8 mM HU to wild type cells.
ORGANISM(S): Schizosaccharomyces pombe 
2010-05-16 | E-GEOD-10901 | biostudies-arrayexpress
UnknownCulicoides jiangchengensis, a new species of the subgenus Sinocoides (Diptera, Ceratopogonidae) based on integrative taxonomy from China.
Not available
S-EPMC10370730 | biostudies-literature
ProteomicsTargeting of Tumor Cells by the Adenovirus E4orf4 protein via Par3 Polarity Protein-Regulated Nuclear Envelope Rupture
The protein product of the Early region 4 open reading frame 4 (E4orf4) of human adenovirus 2 is reported to exhibit a tumor-selective cell killing activity. Here, we show that E4orf4’s tumoricidal activity correlated with changes in perinuclear actomyosin contractility that are controlled by an in...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD014329 | Pride
Lamin a/c Polarity proteins Actin Live cell dynamics Nuclear bleb E4orf4 
TranscriptomicsSchizosaccharomyces pombe ployg mutant cells expression profile.
Expression profiles of polg mutant cells reveal that many genes encoding proteins involved in cell wall biogenesis and stress response are induced, suggesting that polg mutant cells attempt to maintain growth potential and undergo extensive oxidative metabolism. Conversely, many genes encoding prot...
ORGANISM(S): Schizosaccharomyces pombe 
2007-09-28 | E-GEOD-5941 | biostudies-arrayexpress
TranscriptomicsGenomic mapping of Six1 binding sites during skeletal myoblast differentiation
In this study, the C2C12 cell line, a model used to study myogenesis and regeneration, was allowed to differentiate from myoblast precursor cells to myotubes. Cells were harvested at 3 different timepoints to perform ChIP-on-Chip of Six1, which is a key muscle regulator. We identified global loci bo...
ORGANISM(S): Mus musculus 
2010-07-05 | E-GEOD-20150 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiling of siRNA Knock-Down of Six1, Six4 and Myogenin in C2C12
Six1, Six4 and Myogenin are transcription factors that are known to be required for skeletal myogenesis. Currently, very little is known about the genes targeted by Six1 and Six4. Gene expression profiling when one or both transcription factors were knock-down by siRNA was performed to identify gene...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-19967 | biostudies-arrayexpress
UnknownLow Bone Turnover Markers in Young and Middle-Aged Male Patients with Type 2 Diabetes Mellitus.
Not available
S-EPMC7436354 | biostudies-literature
UnknownLack of association of -607 C/A and -137 G/C polymorphisms in interleukin 18 gene with susceptibility to gout disease in Chinese Han male population.
Not available
S-EPMC3364418 | biostudies-literature
UnknownNovel Bronsted Acid Catalyzed C-C Bond Activation and α-Alkylation of Ketones.
Not available
S-EPMC11397341 | biostudies-literature
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