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ModelsLiu2023 - Acinetobacter baumannii growth inhibition prediction with Deep Learning
This model is a Chemprop neural network trained with a growth inhibition dataset. Authors screened ~7,500 molecules for those that inhibited the growth of A. baumannii in vitro. They discovered abaucin, an antibacterial compound with narrow-spectrum activity against A. baumannii. Model Type: Predic...
2024-05-28 | MODEL2405080001 | BioModels
Machine Learning Model FAIR-AIML Ersilia 
ProteomicsFight-or-flight responses require augmentation of Ca2+ influx via Rad phosphorylation
Fight-or-flight responses involve β-adrenergic-induced increases in heart rate and contractile force. Despite decades of investigations, predominantly focusing on ryanodine receptor and phospholamban phosphorylation, the molecular mechanisms underlying the sympathetic nervous system control of cardi...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-26 | PXD033492 | Pride
Contractility Heart Mass spectrometry Adrenergic Calcium Phosphorylation Pka Phosphatases Ion channels 
ProteomicsHippocampal proteome in human model of Temporal Lobe Epilepsy
To scrutinize the proteomic changes that occur in human temporal lobe epilepsy, we compare peptides present in tissue from sclerotic and non-sclerotic temporal lobe epilepsy resected hippocampi and from non-epilepsy autopsy control tissue
ORGANISM(S): Homo sapiens (Human) 
2025-07-28 | PXD064519 | Pride
Human Ms/ms Tle Temporal lobe epilepsy 
UnknownQuantitative texture analysis using machine learning for predicting interpretable pulmonary perfusion from non-contrast computed tomography in pulmonary embolism patients.
Not available
S-EPMC11520386 | biostudies-literature
TranscriptomicsAntioxidant response gene expression in the bronchial airway epithelial cells of smokers at risk for lung cancer
Prior microarray studies of smokers at high risk for lung cancer have demonstrated that heterogeneity in bronchial airway epithelial cell gene expression response to smoking can serve as an early diagnostic biomarker for lung cancer. This study examines the relationship between gene expression vari...
ORGANISM(S): Homo sapiens 
2010-09-30 | E-GEOD-19027 | biostudies-arrayexpress
ProteomicsData Descriptor: Proteomic profiling across breast cancer cell lines and models
We performed quantitative proteomics of 60 human-derived breast cancer cell lines to a depth of ~13,000 proteins. The resulting high-throughput datasets were assessed for quality and reproducibility. We used the two omics datasets to identify and characterize the subtypes of breast cancer and showed...
ORGANISM(S): Homo sapiens (Human) 
2023-03-15 | PXD026581 | Pride
Protein expression Tmt Proteomic profiling Quantitative proteomics Breast cancer cell lines 
ModelsShestov2014 - aerobic glycolysis
No description
2015-04-15 | MODEL1504010000 | BioModels
TranscriptomicsPIAS3 induction of apoptosis in non-small cell lung cancer cells is p53-independent and has STAT3-independent mediator.
Protein inhibitor of activated STAT3 (PIAS3) is an endogenous inhibitor of STAT3 that negatively regulates STAT3 transcriptional activity and cell growth and demonstrates limited expression in the majority of human squamous cell carcinomas of the lung. In the present study we sought to determine if ...
ORGANISM(S): Homo sapiens 
2012-12-19 | E-GEOD-42979 | biostudies-arrayexpress
TranscriptomicsLudwig Institute/UCSD ENCODE project June 2007 Release
The readout of genome information is controlled by transcriptional regulatory elements, but a comprehensive view of the combinatorial control by these DNA sequences, which bind regulatory protein and/or the modified histones in regulating gene transcription, is clearly preliminary. We have developed...
ORGANISM(S): Homo sapiens 
2007-06-01 | E-GEOD-7872 | biostudies-arrayexpress
TranscriptomicsDifferential roles of promoters, enhancers, and insulators in cell-type specific gene expression
Chromatin immunoprecipitation was performed using antibodies against CTCF and formaldehyde crosslinked chromatin from K562 Chromatin cells. The immunoprecipitated DNA was amplified, fluorescently labeled and hybridized to a 391K element tiling array based on NCBI35 build of the human genome (hg17) t...
ORGANISM(S): Homo sapiens 
2010-05-17 | E-GEOD-8098 | biostudies-arrayexpress
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