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TranscriptomicsHaloarcula hispanica wild-type strain cultured in different media: MG vs 168
Transcriptional profiling of Haloarcula hispanica wild-type strain cultured in different media comparing MG medium with 168 medium. H. hispanica wild-type strain can accumulate PHBV in MG medium, while can not in 168 medium. Goal was to explore the PHA biosynthesis and its impact on central metaboli...
ORGANISM(S): Haloarcula hispanica 
2013-01-22 | E-GEOD-42798 | biostudies-arrayexpress
TranscriptomicsGenes differentially expressed Haloarcula hispanica strains: PHB (M-NM-^TphaEC mutant) vs 960 (wild type)
Transcriptional profiling of Haloarcula hispanica comparing PHB with 960. PHB represents the PHA synthase genes mutant (i.e., M-NM-^TphaEC) which is deficient in PHBV accumulation when grown in MG medium. 960 represents the wild-type strain which can produce PHBV when grown in MG medium. Goal was to...
ORGANISM(S): Haloarcula hispanica 
2013-01-22 | E-GEOD-42799 | biostudies-arrayexpress
TranscriptomicsProteome reference map of Haloarcula hispanica and comparative proteomic and transcriptomic analysis of polyhydroxyalkanoate biosynthesis under genetic and environmental perturbations
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Haloarcula hispanica 
2013-01-22 | E-GEOD-42800 | biostudies-arrayexpress
UnknownMolecular characterization of a rice mutator-phenotype derived from an incompatible cross-pollination reveals transgenerational mobilization of multiple transposable elements and extensive epigenetic instability.
Not available
S-EPMC2696445 | biostudies-literature
TranscriptomicsTLR4 ligands LPS and MPLA differentially regualte effector and memory CD8 T cell differentiation
Here we implemented a simple dendritic cell (DC)-mediated immunization approach to study the effects of commonly used adjuvants, Toll like receptor (TLR) ligands, on effector CD8 T cell differentiation and memory T cell development. To our surprise, we found that the TLR4 ligand LPS was far more sup...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-50764 | biostudies-arrayexpress
ProteomicsQuantative pTyr protein complex
Our current research focuses on the complex-centric quantification of pTyr protein complexes. We initially constructed a tri-functional probe based on pTyr superbinder (SH2-S) for the enrichment of pTyr protein complexes. The pTyr protein complexes were separated by ion exchange chromatography (IEC)...
ORGANISM(S): Homo Sapiens 
2024-05-31 | PXD052742 |
ProteomicsA Tyrosine, Histidine-Selective Bifunctional Cross-linker for Protein Structure Analysis
A novel cross-linking strategy based on this cross-linker has been developed and demostrated, which provides a complementary XL-MS tool analyzing protein structure
ORGANISM(S): Homo Sapiens 
2022-12-03 | PXD036600 |
ProteomicsArginine methylation of METTL14 promotes RNA N6-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells
m6A is the most abundant modification of mRNA in mammals and plays an important role in human development and disease. METTL14 is a key component of m6A methyltransferase complex. The project showed that its post-translational arginine methylation can regulate the generation of m6A and the endoderm ...
ORGANISM(S): Homo Sapiens 
2021-05-17 | PXD018458 |
ProteomicsInterplay between acetylation and ubiquitination of Isw1 confers multidrug resistance in Cryptococcus neoformans
Lysine acetylation and ubiquitination are one of many protein modifications and play a crucial role in the biological regulation of many organisms, but little is known about the relationship between acetylation and ubiquitination few. Here, the Isw1 protein is an important member of the chromatin re...
ORGANISM(S): Cryptococcus Neoformans Var. Grubii H99 
2023-09-13 | PXD045338 |
ProteomicsHypoxia Regulates Overall mRNA Homeostasis by Inducing Met1-linked Linear Ubiquitination of AGO2 in Cancer Cells
Hypoxia is the most prominent feature in human solid tumors and induces activation of hypoxia-inducible factors and their downstream genes to promote cancer progression. However, whether and how hypoxia regulates overall mRNA homeostasis is unclear. Here we show that hypoxia inhibits global-mRNA dec...
ORGANISM(S): Homo Sapiens 
2021-04-06 | PXD021722 |
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