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UnknownThe Response of Rhizosphere Microbial C and N-Cycling Gene Abundance of Sand-Fixing Shrub to Stand Age Following Desert Restoration.
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S-EPMC11434391 | biostudies-literature
ProteomicsIntegration of transcriptomics, proteomics and metabolomics data to reveal the biological mechanisms of abrin injury in human lung epithelial cells
we performed a comprehensive analysis of transcriptomics, proteomics and metabolomics on the potential mechanism of abrin injury in human lung epithelial cells.
ORGANISM(S): Homo Sapiens 
2019-01-18 | PXD012435 |
ProteomicsCardiomyocyte-Derived HSPB1 Regulates TGF-β1 Maturation and Inhibits Endothelial-to-Mesenchymal Transition in Myocardial Fibrosis after Infarction
Myocardial fibrosis is a major contributor to heart failure after myocardial infarction (MI), primarily driven by endothelial-to-mesenchymal transition (EndoMT). Heat shock protein B1 (HSPB1) has cardioprotective functions, but its role in MI-induced fibrosis remains unclear. Here, we show that card...
ORGANISM(S): Homo Sapiens 
2025-12-22 | PXD072325 |
ProteomicsProteome profiling of lung tissues in chronic obstructive pulmonary disease (COPD): disfunction of platelet and macrophage contribute to pathogenesis of COPD
Chronic obstructive pulmonary disease (COPD) is a worldwide public health challenge because of its high prevalence and related disability and mortality; however, the pathogenesis of COPD remains unknown. The aim of this study was to reveal the critical proteins involved in the pathogenesis of COPD. ...
ORGANISM(S): Homo Sapiens 
2020-01-17 | PXD017158 |
ProteomicsProteomic Profiling of Inflammatory versus Noninflammatory Cartilage Regions in Knee Osteoarthritis Patients
This study performed data-independent acquisition (DIA)-based quantitative proteomic analysis on paired cartilage samples from inflammatory and noninflammatory regions of knee osteoarthritis (OA) patients. The objective was to characterize the proteomic alterations associated with cartilage inflamma...
ORGANISM(S): Homo Sapiens 
PXD078593 |
ProteomicsLC-MS/MS analysis for femoral vein of rat with deep venous thrombosis
Secondary pathological changes after vascular injury include all the pathophysiology factors that cause thrombosis. However, this procedure is still complicated and volatile. Discovering new pathological changes associated with trauma and clarifying its mechanism is an important theoretical suppleme...
ORGANISM(S): Rattus Norvegicus 
2022-03-17 | PXD032343 |
ProteomicsTestosterone delays bone loss and microstructural destruction in elderly men via osteoblast-androgen receptor-mediated upregulation of the fibrinogen C-terminus of tenascin-C
Bone loss in elderly males is associated with a high mortality rate because of fracture. A growing body of evidence indicates that low androgen levels are linked with bone loss in elderly men, suggesting that the regulatory role of androgen in aged male bones deserves more attention, and it is not e...
ORGANISM(S): Mus Musculus 
PXD052247 |
ProteomicsThe influence of IL-1β and TNF-α on the tenogenic differentiation of human periodontal ligament stem cells via global proteomic analysis
The hPDLSCs were cultured in the tenogenic medium treated with 0.1 ng/ml IL-1β or 10 ng/ml TNF-α for 7 days. Total proteins were isolated from the collected cell samples. Subsequently, the LFQ-based proteomic analysis was conducted for the extracted proteins in each group as established procedures...
ORGANISM(S): Homo Sapiens 
PXD056585 |
ProteomicsSARS-CoV-2 ORF10 impairs cilia by enhancing CUL2ZYG11B activity
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causal pathogen of the ongoing global pandemic of coronavirus disease 2019 (COVID-19). Loss of smell and taste are new identified symptoms of COVID‐19, and both of these are related to cilia dysfunction. However, the pathological me...
ORGANISM(S): Homo Sapiens 
2022-02-23 | PXD031842 |
ProteomicsBCAT1 Confers Resistance to EGFR TKIs through α-KG-dependent Epigenetic Regulation of the Glycolysis Pathway in NSCLC
Epidermal growth factor receptor (EGFR) mutations are leading oncogenic drivers in non-small cell lung cancer (NSCLC). Many third-generation EGFR tyrosine kinase inhibitors (TKIs) have been developed to target EGFR T790M and activating mutations. Osimertinib (AZD9291) was the first approved drug and...
ORGANISM(S): Homo Sapiens 
PXD043776 |
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