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UnknownPRMT2 silencing regulates macrophage polarization through activation of STAT1 or inhibition of STAT6.
Not available
S-EPMC10765854 | biostudies-literature
TranscriptomicsIdentification of miRNAs and their target genes in developing maize ears by deep sequencing
In plants, MicroRNAs (miRNAs) are a new class of endogenous small RNAs that play essential regulatory roles in plant growth, development and stress response. Extensive studies of miRNAs have been performed in model plants such as rice, Arabidopsis thaliana and other plants. However, the number of mi...
ORGANISM(S): Zea mays 
2014-10-22 | E-GEOD-47837 | biostudies-arrayexpress
TranscriptomicsA genome-wide functional investigation into the roles of differentially expressed genes and microRNAs, including 24 transcription factor families, in tobacco roots during the drought stress response
Drought stress response is a complex trait regulated at multiple levels. In the past few years, molecular and genomic studies have shown that several drought responsive genes (DRGs) with various functions are induced by drought stresses, and that various transcription factors (TFs) are involved in t...
ORGANISM(S): Nicotiana tabacum 
2013-12-20 | E-GEOD-43058 | biostudies-arrayexpress
ProteomicsBailixiang tea, an herbal medicine formula, co-suppresses TLR2/MAPK8 and TLR2/NF-κB signaling pathways to protect against LPS-triggered cytokine storm in mice
we aimed to explore the molecular mechanism underlying its effects through blood proteomics and transcriptomics analyses. To achieve this, mice were orally administered BLX for 24 h after being treated with 5 mg/kg lipopolysaccharide (LPS). The results demonstrated that BLX effectively down-regulate...
ORGANISM(S): Mus Musculus 
PXD051353 |
TranscriptomicsGenome-wide comparative analysis of digital gene expression tag profiles during maize ear development
The present study profiled and analyzed gene expression of the maize ear at four key developmental stages. Based on genome-wide profile analysis, we detected differential mRNA of maize genes. Some of the differentially expressed genes (DEGs) were predicted to be potential candidates of maize ear dev...
ORGANISM(S): Zea mays 
2015-04-30 | E-GEOD-49805 | biostudies-arrayexpress
UnknownIn vivo neutrophils hitchhiking for tumor targeting and microenvironment regulation boosts oncolytic virus therapy.
Not available
S-EPMC12490210 | biostudies-literature
UnknownRemolding the tumor microenvironment by bacteria augments adoptive T cell therapy in advanced-stage solid tumors.
Not available
S-EPMC11582571 | biostudies-literature
ProteomicsRepurposing homoharringtonine for thyroid cancer therapy through TIMP1/FAK/PI3K/AKT signaling pathway
Homoharringtonine (HHT), an alkaloid isolated from Cephalotaxus, is an effective anti-leukemia agent that also exhibits inhibitory effects in various solid tumors. However, the impacts of HHT treatment on thyroid cancer (TC) remain unclear. This study aimed to explore whether HHT has anti-TC effects...
ORGANISM(S): Homo Sapiens 
2024-03-03 | PXD050295 |
ProteomicsHOTAIR knockdown glioma cell proteomics
This study demonstrated the effects of lncRNA HOTAIR knockdown on the glioma proteomics. An abnormally high expression of the lncRNA HOTAIR has been previously demonstrated in glioma cells. HOTAIR regulates genes by anchoring epigenetic modification proteins and causes abnormalities in multiple sign...
ORGANISM(S): Homo Sapiens 
2021-12-31 | PXD029919 |
ProteomicsSerum proteomic features of active and recovered COVID-19 patients: potential diagnostic and prognostic biomarkers
The early diagnosis and prognosis of COVID-19, the disease caused by SARS-CoV-2 infection remain major challenges. Clinical information assessment combined with biomarkers based on molecular changes is of great value in the diagnosis and prognosis of COVID-19. However, the biomarkers for COVID-19 ha...
ORGANISM(S): Homo Sapiens 
2020-10-13 | PXD021954 |
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