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UnknownMachine learning predictor to investigate treatment modalities and overall survival in HER2+ patients with early-stage breast cancer.
Not available
S-EPMC12617624 | biostudies-literature
MetabolomicsGut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy
Numerous studies found intestinal microbiota alterations which are thought to affect the development of various diseases through the production of gut-derived metabolites. However, the specific metabolites and their pathophysiological contribution to cardiac hypertrophy or heart failure progression ...
2021-12-08 | MTBLS3174 | MetaboLights
Proteomicscomparative proteome analysis of serum exosomes from newborn piglets inresponse to porcine epidemic diarrhea virus infection
The immune system is thought to be fragile in the neonate, which is susceptible to pathogens. Exosomes are a type of vehicles existing in the body fluid and participate in many biological processes, especially the immune response. Inorder to investigate the roles that exosomes may play during virus ...
ORGANISM(S): ssRNA viruses Sus scrofa domesticus (domestic pig) 
2019-04-30 | PXD010762 | Pride
Neonate Complement Serum exosome Porcine epidemic diarrhea virus Antiviral effect 
MetabolomicsUnraveling the metabolic effects of benzophenone-3 on the endosymbiotic dinoflagellate Cladocopium goreaui

As a well-known pseudo-persistent environmental pollutant, oxybenzone (BP-3) and its related organic ultraviolet (UV) filters have been verified to directly contribute to the increasing mortality rate of coral reefs. Previous studies have revealed the potential role of symbiotic Symbiodiniaceae i...

2023-02-21 | MTBLS6890 | MetaboLights
UnknownMixed adverse ergonomic factors exposure in relation to work-related musculoskeletal disorders: a multicenter cross-sectional study of Chinese medical personnel.
Not available
S-EPMC12034785 | biostudies-literature
ProteomicsFOXA1 O-GlcNAcylation-mediated transcriptional switch governs metastasis capacity in breast cancer
The forkhead protein FOXA1 has been found to play a critical role in orchestrating hormonal-signaling network and to function as a pioneer factor to regulate breast-specific gene expression,However, whether interplay between O-GlcNAcylation and FOXA1 affects the genome-wide transcriptional activity ...
ORGANISM(S): Homo Sapiens 
2022-12-21 | PXD039019 |
ProteomicsChromatin bound O-GlcNAc proteins related to stress response and transcriptional regulation.
O-GlcNAcylation performs a critical role in regulating stress response program and cellular homeostasis. However, systematic studies of O-GlcNAc regulated genotoxic stress-responsive transcriptional reprograming have been limited. The GalNAz metabolic labeled global chromatin-associated proteins wer...
ORGANISM(S): Homo Sapiens 
PXD016713 |
ProteomicsO-GlcNAcylation elevates topoisomerase IIα catalytic activity: a role in the chemotherapy resistance of breast cancer
DNA topoisomerase IIα (TOP2A) plays a vital role in replication and cell division by catalytically altering DNA topology. It is a prominent target for anticancer drugs. However, it is currently unknown whether TOP2A is O-GlcNAc-modified, and the mechanism by which interplay between TOP2A and O-GlcNA...
ORGANISM(S): Homo Sapiens 
PXD041284 |
ProteomicsProbing the Role of O-GlcNAcylation in Modulating Protein-DNA Interactions: Insights from a Proteomic Transcription Factor Response Element-Based Pulldown Screening Approach
O-linked β-N-acetylglucosamine (O-GlcNAc), a critical post-translational modification (PTM) predominantly found in the nucleus, plays a substantial role in regulating gene expression by modulating transcription factors (TFs) activity. Herein, by utilizing a pulldown screening approach termed as tand...
ORGANISM(S): Homo Sapiens 
PXD057128 |
ProteomicsChromatin-associated OGT promotes hepatocellular carcinoma malignancy via activating ZNF263
OGT, the only facilitator which attaches the monosaccharide to many oncogenic factors or tumor suppressors, has been suggested to play an influential role in tumorigenesis and metastasis of HCC. OGT interactome analyses indicates that disordered OGT may serve as a hub protein to activate the buildin...
ORGANISM(S): Homo Sapiens 
2023-01-12 | PXD039365 |
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