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ProteomicsSerum proteomics of wild type mice and Mdm2 adipocyte-specific knock-in mice fed high-fat diet
The serum samples from wild type mice fed high-fat diet for 12 weeks (WT_Serum) and Mdm2 adipocyte-specific knock-in mice fed high-fat diet for 12 weeks (KI_Serum) were mixed separately, and subjected to proteomic study by Label-free quantitative techniques and mass spectrometry-based proteomics tec...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-11 | PXD034069 | Pride
Serum Proteomics Mice Wild type Mdm2 
ProteomicsThe eWAT proteomics of wild type mice and Mdm2 adipocyte-specific knock-in mice fed high-fat diet
The epididymal adipose tissue (eWAT) samples from wild type mice fed high-fat diet for 12 weeks (H_WT_E) and Mdm2 adipocyte-specific knock-in mice fed high-fat diet for 12 weeks (H_KI_E) were mixed separately, and subjected to proteomic study by Label-free quantitative techniques and mass spectromet...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-11 | PXD034074 | Pride
Proteomics Ewat Mice Mdm2 High-fat diet 
ProteomicsIdentification of novel KRT32-associated proteins in primary keratinocytes cells lysate by GST-KRT32 pulldown assays coupled with mass spectrometry.
GST-KRT32 and its interacting proteins in primary keratinocytes cells were enriched by pull-down using glutathione-Sepharose beads. Then, KRT32-interacting proteins were identified by mass spectrum. Proteins obtained in Pulldown were subjected to SDS-PAGE gel electrophoresis and silver staining. The...
ORGANISM(S): Homo sapiens (Human) 
2024-06-17 | PXD050141 | Pride
Keratin  krt32 
ProteomicsDysregulation of N-glycosylation by RPN1 knockout in spermatocytes induces male infertility via impaired mitochondrial function in mice
N-glycosylation protein modifications play a crucial regulatory role in numerous biological processes, although their contribution to male reproduction in mammals remains largely undefined. Here, we found that Ribophorin I (RPN1), a subunit of oligosaccharyltransferase complex, is indispensable for ...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD051379 | Pride
Rpn1  n-glycosylation  meiosis  spermatogenesis  fertility 
ProteomicsHK-2 cells 4D label quantitative lactylproteomic analysis
Following acute kidney injury (AKI), a substantial subset of patients experiences an irreversible progression to chronic kidney disease (CKD), yet the molecular determinants governing this maladaptive transition remain elusive, and effective clinical interventions are lacking. Here, we identify lact...
ORGANISM(S): Homo sapiens (Human) 
2026-07-18 | PXD078736 | Pride
Human  lactylation 
ProteomicsPhosphoproteomics reveals regulation of secondary metabolites in Mahonia bealei under ultraviolet-B radiation
Mahonia Bealei was used as a traditional Chinese medicine for its high alkaloid content. Previous research found that alkaloid and flavonoid contents in the M. bealei leaves increased under combinatory treatments of ultraviolet B and dark. In order to explore the underlying response mechanism, TiO2 ...
ORGANISM(S): Mahonia 
2022-02-16 | PXD028873 | Pride
Phosphoproteomics  mahonia bealei  ultraviolet-b radiation  abiotic stress  secondary metabolism 
UnknownProteomic and Phosphoproteomic Insights into a Signaling Hub Role for Cdc14 in Asexual Development and Multiple Stress Responses in Beauveria bassiana.
Not available
S-EPMC4824431 | biostudies-literature
UnknownHistone acetyltransferase 1 is a succinyltransferase for histones and non-histones and promotes tumorigenesis.
Not available
S-EPMC7857430 | biostudies-literature
ProteomicsUBE2J2 is essential for the progression of meiosis prophase I during spermatogenesis in mice
For proteomics analysis, testes of Ube2j2-/- and WT mice were collected on ice, washed once with pre-cooled PBS, dried with absorbent paper, and immediately placed in liquid nitrogen, dry ice, or at -80 ℃. Samples were packed in dry ice and transported to Hangzhou Jingjie Biotechnology Company (PTM ...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-05 | PXD063637 | Pride
Meiosis arrest Synaptonemal complex disassembly. Ube2j2 Homologous recombination 
UnknownProteomic Analysis Reveals Molecular Differences in the Development of Gastric Cancer.
Not available
S-EPMC9357686 | biostudies-literature
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