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ProteomicsAcute to prolonged lif cycle proteomic profiling of heat shock SGs
Time-resolved proteomic profiling of SGs from cultured human U2OS cells over a prolonged heat-shock (HS) and a successive recovery period, sampling at the 6 time points of HS exposure (10, 20, 30, 60, 120, 180 min), as well as 2 time points of recovery (5, 10 min). From the sampled cells, we prepare...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-08-30 | MSV000092790 | MassIVE
TranscriptomicshTERT promotes cell adhesion and migration independent of telomerase activity
We sequenced mRNA from 6 human cell lines stably over-expressed specific gene or empty vector, and searched for differently expressed genes after gene over-expression as compared to empty vector. mRNA levels were compared as following pairs: U2OS+hTERT vs U2OS+vector; U2OS+hTERTmut vs U2OS+vector; V...
ORGANISM(S): Homo sapiens 
2015-09-22 | E-GEOD-73277 | biostudies-arrayexpress
ProteomicsHSPA4 restrains transferrin in dopaminergic neurons to attenuate ferroptosis in a Parkinson’s disease model
Heat shock protein A4 (HSPA4) is a molecular chaperone belonging to the heat shock protein 70 (HSP70) family. This study aims to investigate the antiferroptotic effects of HSPA4 in a Parkinson’s disease (PD) model and explore the underlying mechanisms. Here we show that HSPA4 overexpression reduces ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD067550 | Pride
Dopaminergic neurons Hspa4 Parkinson’s disease Ferroptosis Transferrin 
ProteomicsFlag-GABPα overexpression HEK293T cells LC-MS/MS
Immunoprecipitated by Flag and IgG antibody for protein capture by LC-MS/MS in HEK293T cells infected with GABPα-Flag overexpression plasmid.
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD070466 | Pride
Hek293t cells Gabpα Lc-ms/ms 
MetabolomicsMechanisms of hepatic steatosis in chickens: integrated analysis of the host genome, molecular phenomes and gut microbiome

Hepatic steatosis is the initial manifestation of abnormal liver functions and often leads to liver diseases such as non-alcoholic fatty liver disease in humans and fatty liver syndrome in animals. In this study, we conducted a comprehensive analysis of a large chicken population consisting of 70...

2023-07-24 | MTBLS7808 | MetaboLights
ProteomicsLysosomal-associated protein transmembrane 5, tubular senescence, and progression of CKD
After LAPTM5 was overexpressed in rat renal tubular epithelial cells (NRK52E), proteomic sequencing was performed to analyze aging and fibrosis protein changes.
ORGANISM(S): Rattus Rattus 
2024-06-05 | PXD052845 |
ProteomicsPhosphoproteomic analysis reveals the effects of sleep deprivation on the hippocampus of mice
Sleep deprivation has a significant effect on the level of protein phosphorylation modification in the hippocampus of mice.
ORGANISM(S): Mus Musculus 
2022-06-29 | PXD034972 |
ProteomicsQuantitative Proteomics Reveal the Protective Effects of CuraUltra Against Alzheimer’s Disease via Modulating the Expression of Synapse-associated Proteins in Mouse Model
To identify the potential molecular mechanism responsible for the effect on CuraUltra treatment, label-free quantitative proteomics by tandem mass spectrometry (LC-MS / MS) were performed, which provides in depth characterization of protein profile changes . Critical altered proteins were validated ...
ORGANISM(S): Mus Musculus 
2021-11-10 | PXD029640 |
ProteomicsProteomics analysis reveals the difference between young and old sperm in Sus Scrofa
The objective of this study was to elucidate the underlying proteomic mechanisms responsible for sperm disparities between young and aged boars, with the ultimate goal of enhancing semen quality in aging breeding pigs.
ORGANISM(S): Sus Scrofa Domesticus 
2024-03-21 | PXD050879 |
ProteomicsLymphatic platelet thrombosis limits bone repair by precluding lymphatic transporting DAMPs
In the musculoskeletal system, lymphatic vessels (LVs), which are interdigitated with blood vessels, travel and form an extensive transport network. Blood vessels in bone regulate osteogenesis and hematopoiesis, however, whether LVs in bone affect fracture healing is unclear. Here, we investigated t...
ORGANISM(S): Rattus Norvegicus 
2024-10-05 | PXD056584 |
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