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TranscriptomicsSOX7 and SOX17 DNA binding in baseline HUVEC
SOXF transcription factors are highly relevant for endothelial biology, yet comprehensive binding data of the endogenous proteins in endothelial cells has not previously been published. We used CUT&RUN to determine the binding patterns of endogenous SOX7 and SOX17 in baseline human umbilical vein en...
ORGANISM(S): Homo sapiens 
2025-03-27 | E-MTAB-13999 | biostudies-arrayexpress
ProteomicsInference and quantification of peptidoforms in large sample cohorts by SWATH-MS: Twin blood plasma quantitative variance components
This data set represents a reanalysis of human blood plasma samples measured by SWATH-MS of 36 pairs of monozygotic and 22 pairs of dizygotic twins that were sampled at two longitudinal time points (Liu et al., 2015, PMID:25652787). The data were used to determine the overall quantitative variabilit...
ORGANISM(S): Homo sapiens (Human) 
2017-06-06 | PXD004574 | Pride
Ipf Openswath Blood plasma Ptm Human 
TranscriptomicsEnhancer-bound LDB1 Regulates a Corticotrope Promoter Pausing Repression Program [GRO-seq]
Substantial evidence supports the hypothesis that enhancers are critical regulators of cell type determination, orchestrating both positive and negative transcriptional programs; however, the basic mechanisms by which enhancers orchestrate interactions with cognate promoters during activation and re...
ORGANISM(S): Mus musculus 
2015-02-03 | E-GEOD-64515 | biostudies-arrayexpress
TranscriptomicsLigand-Dependent Enhancer Activation Regulated by Topoisomerase-I Activity
The discovery that enhancers are regulated transcription units, encoding eRNAs, has raised new questions about the mechanisms of their activation. Here, we report an unexpected molecular mechanism that underlies ligand-dependent enhancer activation, based on DNA nicking to relieve torsional stress f...
ORGANISM(S): Homo sapiens 
2015-01-22 | E-GEOD-63202 | biostudies-arrayexpress
UnknownTargeted Intracellular Copper Reservoir Enhances Liver Cancer Immunotherapy.
Not available
S-EPMC12423925 | biostudies-literature
UnknownStudy on the linkage between macro policy and market effectiveness in China's stock market: Based on run test of China's stock market index.
Not available
S-EPMC9970056 | biostudies-literature
UnknownWalnut antigens can trigger autoantibody development in patients with pemphigus vulgaris through a "hit-and-run" mechanism.
Not available
S-EPMC6742533 | biostudies-literature
TranscriptomicsEnhancer Activation Requires Trans-Recruitment of a Mega Transcription Factor Complex (Gro-seq)
Enhancers provide critical information directing cell-type specific transcriptional programs, regulated by binding of signal-dependent transcription factors and their associated cofactors. Here we report that the most strongly activated estrogen (E2)-responsive enhancers are characterized by trans-r...
ORGANISM(S): Homo sapiens 
2014-10-09 | E-GEOD-60271 | biostudies-arrayexpress
MetabolomicsA Cross-Platform Metabolomics Comparison Identifies Serum Metabolite Signatures of Liver Fibrosis Progression in Chronic Hepatitis C Patients
Metabolomics offers new insights into disease mechanisms that is enhanced when adopting orthogonal instrumental platforms to expand metabolome coverage, while also reducing false discoveries by independent replication. Herein, we report the first inter-method comparison when using multisegment injec...
2023-08-22 | MTBLS3111 | MetaboLights
UnknownHigher glutamatergic activity in the medial prefrontal cortex in chronic ketamine users.
Not available
S-EPMC9343127 | biostudies-literature
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