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MetabolomicsDiscovery and validation of potential serum biomarkers for heart failure by untargeted metabolomics

Detection of biomarkers was extremely important for the early diagnosis, prognosis and therapy optimization of diseases. The purpose of this study was to investigate the differences in serum metabolites between patients with heart failure (HF) and healthy controls (HC), and to diagnose HF qualita...

2025-07-18 | MTBLS9586 | MetaboLights
MetabolomicsGallbladder microbial species and host bile acids biosynthesis linked to cholesterol gallstone comparing to pigment individuals

Gallstones are crystalline deposits in the gallbladder that are traditionally classified as cholesterol, pigment or mixed stones based on their composition. Microbiota and host metabolism variances among the different types of gallstones remain largely unclear. Here, the bile and gallstone microb...

2024-03-11 | MTBLS7736 | MetaboLights
ProteomicsUBA2-High Osteosarcoma Suppresses Immune Infiltration by Autophagy-Mediated MHC-I Degradation
Osteosarcoma (OS) responds poorly to immune-checkpoint blockade (ICB), and the molecular drivers of its immune-cold state remain unclear. Using multi-omics analyses, we identified an immune-cold OS subtype characterized by enrichment of protein SUMOylation and found the SUMO E1 subunit UBA2 as a key...
ORGANISM(S): Homo Sapiens 
2026-01-28 | PXD073700 |
UnknownThe deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity
Not available
S-SCDT-EMBOR-2020-51162V1P | biostudies-other
ProteomicsPPP6R3 immunoprecipitation mass spectrometry (IP-MS) data
PPP6R3 IP-MS data using KIT+ spermatogonia purified from testes of P9 wild-type mice
ORGANISM(S): Mus Musculus 
PXD056272 |
ProteomicsEIF5A couples translational control with transcriptional reprogramming through chromocenter reorganization during spermiogenesis
Translation initiation factor eIF5A facilitates protein synthesis and impacts diverse biological processes, yet its role in transcriptional regulation is poorly understood. Here we find eIF5A highly expressed in diverse spermatogenic cell types. Conditional knockout of Eif5a (SKO) causes complete in...
ORGANISM(S): Mus Musculus 
PXD067244 |
ProteomicsCDK9 binds and activates SGK3 to promote cardiac repair after injury via the GSK-3β/β-catenin pathway
SGK3 (threonine-protein kinase 3) is a functional kinase we identified previously with the capacity to promote cardiomyocyte proliferation and cardiac repair after myocardial infarction. However, the upstream signals regulating SGK3 are still unknown. Based on the quantitative proteomics data and pu...
ORGANISM(S): Mus Musculus 
PXD035187 |
Proteomicsproteomic analysis in cataract of Ailuropoda melanoleuca (Giant panda)
proteomic analysis between cataract of Ailuropoda melanoleuca (Giant panda) and normal panda
ORGANISM(S): Ailuropoda Melanoleuca 
2022-01-18 | PXD031039 |
ProteomicsLabel-free quantitative proteomic analysis for normal and inflamed colonic mucosa from patients with ulcerative colitis
Label-free quantitative proteomic analysis for clinical tissues of 5 normal and 5 inflamed colonic mucosa. The EASY-nLC 1200 system and Q Exactive Plus were used for peptides detection. A total of 4102 proteins were identified, and 2713 proteins were quantified. According to the criterion fold chang...
ORGANISM(S): Homo Sapiens 
2025-03-12 | PXD061745 |
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