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MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Human lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-03 | MTBLS8856 | MetaboLights
MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Mice lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-04 | MTBLS8865 | MetaboLights
ProteomicsDIA-based raw mass spectrometry proteomics data of oviduct in goat
DIA-based LC-MS/MS method was used to obtain follicular and luteal phase proteomics data from the oviducts of high- and low-fertility goats, and to mine the oviducts for biomarkers that regulate fertility in goats through bioinformatics analysis of differential proteins.
ORGANISM(S): Capra Hircus 
2022-11-13 | PXD038122 |
ProteomicsExosome-transmitted HSPA9 facilitates bortezomib signaling in multiple myeloma
LC-MS was conducted to screen potential proteins that interacting with HSPA9 in multiple myeloma
ORGANISM(S): Homo Sapiens 
2025-03-13 | PXD061782 |
ProteomicsLoss of Necdin causes social deficit and aberrant synaptic function through destabilization of SynGAP
The Ras GTPase-activating protein SynGAP interacts with PSD95 to regulate synaptic morphology and function at the postsynaptic density in neurons. Haploinsufficiency of SYNGAP1 has been linked to autism spectrum disorders (ASD) and intellectual disability (ID). While transcriptional and translationa...
ORGANISM(S): Mus Musculus 
2025-05-17 | PXD064040 |
ProteomicsProteomic and Phosphoproteomic Analyses during Plant Regeneration Initiation in Cotton (Gossypium hirsutum L.)
Somatic embryogenesis (SE) is a biotechnological tool used to generate new individuals and is the preferred method for rapid plant regeneration. However, the molecular basis underlying somatic cell regeneration through SE is not yet fully understood, particularly regarding interactions between the p...
ORGANISM(S): Gossypium hirsutum 
2025-03-21 | PXD062095 | Pride
Proteomic and phosphoproteomic analyses  somatic embryogenesis  plant regeneration  cotton 
ProteomicsThe Dynll1-Cox4il Complex Regulates Intracellular Pathogen Clearance via Release of Mitochondrial Reactive Oxygen Species
Cellular membrane proteins are a critical part of the host defense mechanisms against infection and intracellular survival of Listeria monocytogenes. The complex spatiotemporal regulation of bacterial infection by various membrane proteins has been challenging to study. Here, using mass spectrometry...
ORGANISM(S): Mus Musculus 
2020-02-17 | PXD016452 |
ProteomicsHMGB2 promote ESCC tumorigenesis and predict neoadjuvant therapy response
Recent studies have demonstrated that chronic stress can enhance the development of multiple human diseases, including cancer. However, the role of chronic stress in esophageal carcinogenesis and its underlying molecular mechanisms remain unclear. This study uncovered that dysregulated cholesterol m...
ORGANISM(S): Mus Musculus 
2025-01-09 | PXD059616 |
ProteomicsChronic stress-induced cholesterol metabolism abnormalities promote ESCC tumorigenesis and predict neoadjuvant therapy response
chronic stress activates the GCR-HMGB2-LDLR axis via cortisol release, leading to abnormal cholesterol metabolism and ultimately promoting esophageal carcinogenesis
ORGANISM(S): Homo Sapiens 
2025-01-09 | PXD059578 |
ProteomicsTargeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome
The efficacy of immunotherapy against colorectal cancer (CRC) is impaired by insufficient immune cell recruitment into the tumor microenvironment. Our study shows that targeting circDNA2v, a circular RNA commonly overexpressed in CRC, can be exploited to elicit cytotoxic T-cell recruitment. CircDNA2...
ORGANISM(S): Homo Sapiens 
2024-04-11 | PXD051359 |
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