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UnknownRole of Tim-3 in hepatitis B virus infection: An overview.
Hepatitis B virus (HBV) infection has received increasing public attention. HBV is the prototypical member of hepadnaviruses, which naturally infect only humans and great apes and induce the acute and persistent chronic infection of hepatocytes. A large body of evidence has demonstrated that dysfunc...
S-EPMC4735003 | biostudies-literature
ProteomicsMoCox6 is a regulator of mitophagy and a druggable target in Magnaporthe oryzae
A convergent screening strategy was employed to systematically identify mitophagy regulators within the IMM. The quantitative proteomic comparison between the WT and ΔMoatg1 mutant under nutrient-replete (CM) and nitrogen-starvation (CM-N) conditions was conducted using TMT-labeled quantitative prot...
ORGANISM(S): Pyricularia oryzae 70-15 
2026-09-14 | PXD075441 | Pride
Mitophagy Succinylation Cox6 Fungicide Magnaporthe oryzae 
MetabolomicsCD73 inhibitor AB680 suppresses glioblastoma in mice by inhibiting purine metabolism and promoting P2RY12<sup>+</sup> microglia transformation.
CD73 (ecto-5'-nucleotidase) is a metabolic immune checkpoint that dephosphorylates AMP to produce adenosine. Adenosine plays a pivotal role in immunosuppressive tumor microenvironment (TME) through adenosine receptors expressed on various immune cells. AB680, a specific CD73 inhibitor, is currently ...
2025-08-04 | MTBLS11084 | MetaboLights
UnknownASH2L upregulation contributes to diabetic endothelial dysfunction in mice through STEAP4-mediated copper uptake.
Endothelial dysfunction is a common complication of diabetes mellitus (DM) and contributes to the high incidence and mortality of cardiovascular and cerebrovascular diseases. Aberrant epigenetic regulation under diabetic conditions, including histone modifications, DNA methylation, and non-coding RN...
S-EPMC10834535 | biostudies-literature
UnknownA Bayesian network meta-analysis of the primary definitive therapies for locoregionally advanced nasopharyngeal carcinoma: IC+CCRT, CCRT+AC, and CCRT alone.

Background

The major aim of this Bayesian network analysis was to determine the optimal treatment strategy for locoregionally advanced nasopharyngeal carcinoma (LANPC).

Method

We systematically searched databases and extracted data from randomized clinical trials involving LANPC patie...
S-EPMC8932567 | biostudies-literature
UnknownWhole-exome sequencing analysis identifies distinct mutational profile and novel prognostic biomarkers in primary gastrointestinal diffuse large B-cell lymphoma.

Background

Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive non-Hodgkin lymphoma, and about 10% of DLBCL cases primarily occur in the gastrointestinal tract. Previous reports have revealed that primary gastrointestinal-DLBCL (pGI-DLBCL) harbors different genetic mutations ...
S-EPMC9569083 | biostudies-literature
UnknownCD38 promotes angiotensin II-induced cardiac hypertrophy.
Cardiac hypertrophy is an early hallmark during the clinical course of heart failure and regulated by various signalling pathways. Recently, we observed that mouse embryonic fibroblasts from CD38 knockout mice were significantly resistant to oxidative stress such as H2 O2 -indu...
S-EPMC5542907 | biostudies-literature
UnknownCD38 Deficiency Protects the Heart from Ischemia/Reperfusion Injury through Activating SIRT1/FOXOs-Mediated Antioxidative Stress Pathway.
Ischemia/reperfusion (I/R) injury induces irreversible oxidative stress damage to the cardiac muscle. We previously observed that CD38 deficiency remarkably protects mouse embryonic fibroblasts (MEFs) from oxidative stress-induced injury. However, whether CD38 deficiency protects from I/R injury in ...
S-EPMC4983367 | biostudies-literature
UnknownHigh Serum Asprosin Levels Are Associated with Presence of Metabolic Syndrome.

Objective

Asprosin, a new adipocytokine, has reportedly been associated with glucose release, dyslipidemia, and insulin resistance (IR). However, the relationship of asprosin with metabolic syndrome (MetS) remains unknown. This study aimed to investigate serum asprosin levels in MetS as well...
S-EPMC7943292 | biostudies-literature
Unknown5-Hydroxymethylcytosine profiles of cfDNA are highly predictive of R-CHOP treatment response in diffuse large B cell lymphoma patients.

Background

Although R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) remains the standard chemotherapy regimen for diffuse large B cell lymphoma (DLBCL) patients, not all patients are responsive to the scheme, and there is no effective method to predict treatmen...
S-EPMC7879534 | biostudies-literature
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