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MetabolomicsAge-, sex- and proximal-distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates.

The incidence of intestinal diseases increases with age, but the regulators of gut aging and the molecules linking gut aging and diseases remain largely unknown. By profiling the transcriptome, proteome, phosphoproteome and metabolome of 104 Macaca fascicularis large intestinal tissues, ...

2023-12-14 | MTBLS7612 | MetaboLights
MetabolomicsTheabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism
Pu-erh tea displays cholesterol-lowering properties, but the underlying mechanism has not been elucidated. Theabrownin is one of the most active and abundant pigments in Pu-erh tea. Here, we show that theabrownin alters the gut microbiota in mice and humans, predominantly suppressing microbes associ...
2021-11-18 | MTBLS1259 | MetaboLights
TranscriptomicsPKC Activation Induces Inflammatory Response and Cell Death in Human Bronchial Epithelial Cells
A variety of airborne pathogens can induce inflammatory responses in airway epithelial cells, which is a crucial component of host defence. However, excessive inflammatory responses and chronic inflammation also contribute to different diseases in the respiratory system. We hypothesized that the ac...
ORGANISM(S): Homo sapiens 
2013-05-27 | E-GEOD-44747 | biostudies-arrayexpress
MetabolomicsHyocholic acid species as novel biomarkers for metabolic disorders
Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict th...
2021-10-06 | MTBLS2343 | MetaboLights
ProteomicsGlycogen synthesis jump-starts photosynthesis through the G6P shunt in cyanobacteria
Proteomics analysis on Synechococcus elongatus PCC 7942 wild type and glycogen mutant cells. Cells growing under the light and dark incubated cells were analyzed for their protein abundance profile.
ORGANISM(S): Synechococcus Elongatus Pcc 7942 (ncbitaxon:1140) 
2019-03-14 | MSV000083575 | MassIVE
ProteomicsQuantitative analysis of the antibacterial effect of cinnamaldehyde on Staphylococcus aureus based on TMT protein
TMT quantitative proteomics was used to analyze the changes of protein expression in MRSA under the action of CA, and the antibacterial mechanism of CA on MRSA was further revealed.
ORGANISM(S): Staphylococcus Aureus 
2024-08-14 | PXD054851 |
ProteomicsProteome of extracellular vesicles derived from breast cancer cells
MDA-MB-231 cells were irradiated with 10 Gy X-rays and the medium was harvest for extracellular vesicles isolation 24 hours post-irradiation. Proteins carrying by EVs of irradiated and control cells were then analysed by LC-MS.
ORGANISM(S): Homo Sapiens 
2024-04-22 | PXD051650 |
ProteomicsLncRNA-Smad7 mediates cross-talk between Nodal/TGF-β and BMP signaling to regulate cell fate determination of pluripotent and multipotent cells
LC-MS/MS combined with the ChIRP for the mESCs of WT and lncRNA-Smad7 KO
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD036394 | Pride
Mouse lc-ms/ms mescs chirp 
MetabolomicsMg2+ in drinking water exacerbates Salmonella Typhimurium T6SS-mediated intestinal bacterial competition through affecting metabolic reprogramming

By establishing a model of enteritis in mice infected with Salmonella Typhimurium, this study investigates the effects of ion concentration in drinking water on intestinal metabolites and microbiota structure in mice, as well as its influence on pathogen susceptibility and the host-patho...

2025-12-30 | MTBLS12690 | MetaboLights
TranscriptomicsA gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK.
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease consisting of emphysema, small airway obstruction, and/or chronic bronchitis that results in significant loss of lung function over time. METHODS: In order to gain insights into the molecular pathways underlying prog...
ORGANISM(S): Homo sapiens 
2012-09-11 | E-GEOD-27597 | biostudies-arrayexpress
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