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TranscriptomicsSIRT6 regulates redox homeostasis in human mesenchymal stem cells by the transactivation of NRF2
We investigated the effect of SIRT6-knockout on gene expression and H3K4me3 modification profile in human mesenchymal stem cells. RNAs isolated from SIRT6+/+ and SIRT6-/- hMSCs at early and late passages were sequenced, respectively. And, H3K4me3 ChIP-seq was performed upon the SIRT6 deleted hMSC an...
ORGANISM(S): Homo sapiens 
2016-01-04 | E-GEOD-64642 | biostudies-arrayexpress
GenomicsGadd45a promotes DNA demethylation through TDG
Growth arrest and DNA-damage-inducible protein 45 (Gadd45) family members have been implicated in DNA demethylation in vertebrates. However, it remained unclear how they contribute to the demethylation process. Here, we demonstrate that Gadd45a promotes active DNA demethylation through thymine DNA g...
ORGANISM(S): Mus musculus 
2015-05-07 | E-GEOD-62496 | biostudies-arrayexpress
ProteomicsQuantitative proteomics revealed modulation of macrophages by MetQ gene of Streptococcus suis serotype 2.
MetQ gene of Streptococcus suis serotype 2 deletion strain has attenuated antiphagocytosis. However,the mechanism of antiphagocytosis and pathogenesis of MetQ in SS2 has remained unclear. In this study, stable isotope labeling by amino acids in cell culture (SILAC) based liquid chromatography-mass s...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD018091 | Pride
Lc-msms Mouse Raw264.7 cell Silac 
GenomicsA Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging
Our data throw light upon the effect of WRN deficiency on gene expression and epigenomic modification, which indicates aging-associated changes from both genomic and epigenomic level. It was compared between WRN+/+ and WRN-/- in hESCs and hMSCs that the gene expression landscapes and epigenetic modi...
ORGANISM(S): Homo sapiens 
2015-05-13 | E-GEOD-52285 | biostudies-arrayexpress
ProteomicsKDM6A downregulation promotes tumor-prone cytokines expression in cancer-associated fibroblasts by activating enhancers
co-IP assays demonstrate that KDM6A is bound to WDR5, facilitating its association with the COMPASS complex and the polycomb repressive complex at the expected target loci.
ORGANISM(S): Homo Sapiens 
2024-12-04 | PXD058594 |
ProteomicsQuantitative proteomics reveals the antibiotics adaptive mechanism of Aeromonas hydrophila in kanamycin stress
Aeromonas hydrophila is a widespread opportunistic pathogen of aquatic fishes in freshwater habitats. The current emergence of antimicrobial-resistant A. hydrophila has been reported in the world while the bacterial antibiotics adaptive mechanism is still largely known. In this study, using quantita...
ORGANISM(S): Aeromonas Hydrophila Subsp. Hydrophila Al09-71 
2022-04-25 | PXD031300 |
ProteomicsiTRAQ-based proteomic analysis of the regulation for fengycin production by PhoPR two-component system in Bacillus subtilis strain NCD-2
The PhoPR two-component system regulated fengycin production by regulating the biosynthesis of branched amino acids in Bacillus subtilis strain NCD-2
ORGANISM(S): Halobacterium Salinarum 
2020-12-25 | PXD023319 |
ProteomicsSerum antigenome profiling reveals diagnostic models for rheumatoid arthritis
This study presented serum antigen profiling of RA. Among them, three panels of antigens were identified to classify RA, ACPA-positive and ACPA-negative RA patients as diagnostic biomarkers.
ORGANISM(S): Homo Sapiens 
2022-02-08 | PXD031498 |
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