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TranscriptomicsGlobal Transcriptome Analyses of Mammalian Terminal Erythroid Differentiation
Purpose:The purpose of this study is to create unbiased, stage-specific transcriptomes by RNA-seq analyses of pure populations of both murine and human erythroblasts at distinct developmental stages. Methods: Recently developed FACS-based methods (Chen et al, PNAS, Liu et al, Blood, Hu et al Blood) ...
ORGANISM(S): Mus musculus 
2014-03-19 | E-GEOD-53983 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of differentiating human erythroblasts
Human erythroblasts purified from cord blood were cultured in vitro and FACS-sorted into five highly purified populations representing distinct differentiation stages:  proerythroblasts, early basophilic erythroblasts, late basophilic erythroblasts, polychromatophilic erythroblasts, and orthochromat...
ORGANISM(S): Homo sapiens 
2013-12-25 | E-GEOD-53635 | biostudies-arrayexpress
TranscriptomicsIsolation and Transcriptome Analyses of Human Erythroid Progenitors: BFU-E and CFU-E
Burst-forming unit-erythroid (BFU-E) and colony-forming unit-erythroid (CFU-E) cells are erythroid progenitors traditionally defined by colony assays. We developed a flow cytometry-based strategy for isolating human BFU-E and CFU-E cells based on the changes in expression of cell surface markers dur...
ORGANISM(S): Homo sapiens 
2014-10-30 | E-GEOD-61566 | biostudies-arrayexpress
TranscriptomicsThe TMAO Generating Enzyme Flavin Monooxygenase 3 is a Central Regulator of Cholesterol Balance
Circulating levels of the gut microbe-derived metabolite trimethylamine-N-oxide(TMAO) have recently been linked to cardiovascular disease (CVD) risk. Here we performed transcriptional profiling in mouse models of altered reverse cholesterol transport (RCT), and serendipitously identified the TMAO-ge...
ORGANISM(S): Mus musculus 
2014-12-19 | E-GEOD-64326 | biostudies-arrayexpress
ProteomicsProteome and lipidome of Urine-derived Exosomes in Mycobacterium tuberculosis Infected Patients
This study confirmed the aberrant lipids and protein spectrum in exosomes of Mtb infected individuals, uncovered novel potential lipid biomarkers for TB/LTBI diagnosis and revealed integral role of exosomal lipid-raft-dependent biological processes in TB pathogenesis.
ORGANISM(S): Homo Sapiens 
2024-03-04 | PXD050345 |
ProteomicsTMT combined with LC–MS/MS technique to detect protein markers in gastroesophageal junction adenocarcinoma
Gastroesophageal junction adenocarcinoma (GEJA) is a malignant tumor located at the junction of the esophagus and stomach, and its incidence is increasing yearly, while early screening for biological markers is limited. Tandem mass tag (TMT) combined with liquid chromatography-tandem mass spectromet...
ORGANISM(S): Homo Sapiens 
2021-12-08 | PXD030228 |
ProteomicsLC-MS/MS identified the TRIM16-binding proteins
Vascular calcification (VC) is highly prevalent in patients with chronic kidney disease (CKD). To date, effective treatments for VC are still lacking since the underlying mechanisms remains elusive. RNA-sequencing analysis revealed that the E3 ubiquitin ligase Tripartite motif 16 (TRIM16) may be a k...
ORGANISM(S): Homo Sapiens 
2024-03-27 | PXD051036 |
ProteomicsComprehensive analyses of the macrophages infected with avirulent and virulent Mycobacterium tuberculosis strains uncover distinct immune mechanisms and anti-TB effect of treated exosomes
Protein data of exosomes from Mycobacterium tuberculosis-infected macrophages
ORGANISM(S): Homo Sapiens 
2026-05-18 | PXD078478 |
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